conclusions in samples stored in plastic syringes, overestimation of pao2 levels should be noted if samples cooled before analysis. in samples stored in plastic syringes, it is not necessary to store samples in iced water when analysis delayed up to one hour. results pao2 of the samples stored at 0°c was increased significantly after 60 minutes (p = 0.007). the paco2 of the samples kept for 30 ...

The metabolic acidosis resulting from an intense exercise bout is large in crocodilians. Here we studied recovery from this pH perturbation in the American alligator. Metabolic rate, minute ventilation, arterial pH and gases, and strong ion concentration were measured for 10 h after exhaustion to elucidate the mechanisms and time course of recovery. Exhaustion resulted in a significant increase...

Right ventricular adaptation to the increased pulmonary arterial load is a key determinant of outcomes in pulmonary hypertension (PH). Pulmonary vascular resistance (PVR) and total arterial compliance (C) quantify resistive and elastic properties of pulmonary arteries that modulate the steady and pulsatile components of pulmonary arterial load, respectively. PVR is commonly calculated as transp...

Thirty unselected subjects with chronic obstructive pulmonary emphysema were studied. The diagnosis in each instance was substantiated by fluoroscopic observation and evaluation of pulmonary function. Each patient was studied in the fasting state. Intubation was carried out under fluoroscopic control and an indwelling arterial needle was inserted. Continuous gastric suction was applied until su...

The objectives of the present review are to describe the agreement between variables on arterial and venous blood gas analysis (in particular pH, pCO(2) , bicarbonate and base excess) and to identify unanswered questions. MEDLINE search of papers published from 1966 to January 2010 for studies comparing arterial and peripheral venous blood gas values for any of pH, pCO(2) , bicarbonate and base...

Activation of purinergic P2X receptors and transient receptor potential vanilloid type 1 (TRPV1) on muscle afferent nerve evokes the pressor response. Because P2X and TRPV1 receptors are sensitive to changes in pH, the aim of this study was to examine the effects of muscle acidification on those receptor-mediated cardiovascular responses. In decerebrate rats, the pH in the hindlimb muscle was a...

There has been significant advancement in the understanding of genetics pulmonary hypertension (PH), particularly those with heritable or idiopathic arterial hypertension. In addition to genetic variants a primarily vascular disease phenotype, prevalence PH other syndromes is increasingly recognized. We will review current knowledge associated multisystem syndromes. high coexisting cardiac and ...

It has been hypothesized that in chronic obstructive pulmonary disease (COPD), sleep-related hypoxaemia could lead to pulmonary hypertension (PH) and cor pulmonale, even in patients with only mild daytime hypoxaemia. We investigated the relationships between sleep variables and daytime pulmonary haemodynamics in 40 COPD patients with daytime arterial oxygen tension (PaO2) between 60-70 mmHg (8-...

The rat working heart-brain stem preparation (WHBP) is an in situ preparation having many of the advantages associated with in vitro preparations while retaining cardiovascular response functionality and an eupnoeic respiratory motor pattern. The preparation is perfused arterially with an aqueous medium having a much lower oxygen-carrying capacity than blood. To evaluate the efficacy of the art...

Hemoglobin, 13.2 g/dl; WBC, 4,300 p.1; urinalysis, normal; serum creatinine, 1.1 mg/dl; PPD, neg; EGG: right axis deviation. Arterial blood gas analysis on room air: pH, 7.42; PCO2, 32 mm Hg; Pco2, 54 mm Hg; Arterial blood gas analysis after 2.2 mm of exercise pH 7.47 Pco2, 28 mm Hg Pco2, 37 mm *Fmm the DepartmentofThoracicDiseasesandInternal Medicine, Mayo Clinic, Rochester, Minnesota. Reprint...