Neurology and Neurosurgery Depar tment of Hospital Municipal Dr. Mário Gatti, Campinas SP, Brasil: Resident of Neurosurgery of Hospital Municipal Dr. Mário Gatti, Campinas SP, Brasil; Resident of Neuropediatry of Hospital das Clínicas, Universidade de São Paulo, São Paulo SP, Brazil; Neurosurgeon of Instituto de Ciencias Neurologicas (ICNE), Hospital Beneficência Portuguesa, São Paulo SP, Brazi...

Previously considered passive support cells, mural cells—pericytes and vascular smooth muscle cells—have started to garner more attention in disease research, as subclassifications, based on morphology, gene expression, function, have been discovered. Central nervous system (CNS) arteriovenous malformations (AVMs) represent a neurovascular disorder which cells shown be affected, both animal mod...

BACKGROUND AND PURPOSE Hereditary hemorrhagic telangiectasia is an autosomal dominant disease that presents in 10%-20% of patients with various brain vascular malformations. We aimed to report the radiologic features (phenotype) and the genotype-phenotype correlations of brain vascular malformations in hereditary hemorrhagic telangiectasia. MATERIALS AND METHODS Demographic, clinical, genotyp...

Vascular anomalies are classified into vascular tumors and vascular malformations based on the classification system of the International Society for the Study of Vascular Anomalies (ISSVA). Vascular tumors are characterized by proliferation and tumor enlargement, and the most common vascular tumor is infantile hemangioma, while a less common vascular tumor is hemangiopericytoma. Vascular malfo...

In patients with intracerebral arteriovenous malformations (AVMs), symptoms attributed to steal can lead to progressive debilitating deficits. This study was undertaken to determine which morphologic features of the AVM could be correlated with clinical symptoms of steal. Over a 4-year period, 65 patients with intracranial AVMs were evaluated with angiography supplemented by MR (46 cases) and C...

BACKGROUND Acquired arteriovenous malformations (AVMs) can develop after uterine instrumentation. The increased risks of vascular changes, including abnormal placentation, after repeated cesarean sections are well studied. Herein, we describe a patient with delayed hemorrhage from a uterine AVM, following dilation and curettage for a cesarean scar pregnancy. CASE A 32-year-old G3P2 presented ...

AIM This study explored the value of using a vessel fusion technique for visualizing and evaluating the vessel structure of patients diagnosed with arteriovenous malformations (AVMs). MATERIALS AND methods 10 patients with AVMs supplied by multiple cerebral arteries were investigated. The three-dimensional structure of the AVM nidus, feeding arteries, and draining veins were reconstructed fro...

BACKGROUND The primary aim of this study is to demonstrate the feasibility of utilizing doxycycline to suppress matrix metalloproteinase-9 (MMP-9) in brain arteriovenous malformations (AVMs). METHODS Ex-vivo treatment of AVM tissues: Intact AVM tissues were treated with doxycycline for 48 hours. Active and total MMP-9 in the medium were measured. Pilot trial: AVM patients received either doxy...

AIM To determine whether specific clinical and radiographic factors predispose arteriovenous malformations (AVMs) presenting with seizure and to predict the seizure risk for individual AVM patients. MATERIAL AND METHODS Clinical features and cerebral angiograms of consecutive 45 unruptured AVM patients who were diagnosed in our center in a 2-year period were reviewed. Patient data (analysis c...

BACKGROUND AND PURPOSE Arteriovenous malformations are an important etiology of hemorrhagic stroke. However, current imaging modalities and risk do not provide insights into individual AVM hemodynamics and its role in pathophysiology. The aims of this study are to determine whether intracranial 4D flow MR imaging can provide insights into arteriovenous malformation hemodynamics independent of t...