AIM This study was designed to examine whether trehalose could protect corneal epithelial cells in culture from death by desiccation in order to test trehalose as a potential new eye drop for dry eye syndrome. METHODS Human corneal epithelial cells in near confluent culture in wells of a 96 well multidish were preincubated for 15 minutes with 2, 20, 50, 100, or 200 mM trehalose or maltose in ...

AIMS/BACKGROUND The aim of this study was to assess quantitatively the effectiveness of hyaluronan on corneal disruption in patients with dry eye. Corneal epithelial barrier function was evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer. METHODS 11 patients with dry eye were assigned to this study. Hyaluronan ophthalmic solution (0.1% hyaluronic acid) was inst...

background: normal bacterial flora of the conjunctiva, which inhibits growth of opportunistic organisms, has an important role in the prevention of ocular infections. if resident flora is inhibited by disease or long-term application of antibiotics, opportunistic pathogens overgrow, leading to disease. objectives: the aim of this study was to investigate the effects of ophthalmic chloramphenico...

in order to increase the water content and the oxygen permeability of hydrogels used in themanufacture of contact lenses, the polar monomer silicon hydrogel contact lenses (shcl), and 2-hydroxyethyl methacrylate (hema) were copolymerized with the hydrogels. due to the presence ofpolar monomers in the conventional contact lenses, the major component of the human tear,lysozyme is extensively adso...

The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS). Twenty five dogs with KCS treated with a topical carbomer (CA)-based tear replacement gel were moved to treatment with a hyaluronic acid (HA)-containing tear replacement eye drop. Dogs were subject to a fu...