Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1), 27.73 μM for A/Guangdong/03/2009 (H1N1), and 25.13 μM ...

A novel series of mesotetrakis[aryl]-21H,23H-porphyrin derivatives 2a-j was synthesized from the condensation of aldehyde derivatives 1a-j with pyrrole in the presence of p-toluenesulfonic acid. The synthesized porphyrins were considered as a model to study the free radical-induced damage of biological membranes and the protective effects of these porphyrins. It was found that these compounds e...

In this paper, we describe the efficient and selective synthesis of aryldipyrromethanes in aqueous medium by acid-catalyzed (HCl) condensations of aromatic aldehydes with 3 equivalents of pyrrole at room temperature. The precipitated aryldipyrromethanes can be isolated directly from the reaction mixture in an essentially pure state by simple filtration. Time control seems to be essential to avo...

The α-methylated chalcone 3 with an electron-donor substituted A-aryl ring and unsubstituted B-phenyl was synthesized by base-catalyzed aldehyde/acetophenone condensation. Compound can be photo-switched from E→Z irradiation long-wavelength light λ > 350 nm, whereas shorter wavelengths leads to photo-stationary states (PSS) lower amounts of the Z-isomer. limiting wavelength for fully equilibr...

Microwave assisted green synthesis of α, ά- bis (substituted- benzylidene) alkanones by the crossed- aldol condensation reaction of substituted aryl aldehydes with ketones in the presence of catalytic amount of NbCl5 in good to excellent yields. This reaction is carried out under solvent-free conditions. The results showed that aldehydes bearing electron–donating substituent's on phenyl-ring fa...

Nano-graphene oxide was synthesized by the oxidation of graphite powders. The structural nature of the nano-graphene oxide was characterized by a variety of techniques including XRD, TEM, FT-IR and UV/Vis. The functional groups on its basal planes and edges of nano-grahene oxide play important role in catalytic activity. The catalytic activity of nano-graphene oxide was investigated on Crossed-...

ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...

Synthesis of 4-(N,N- dimethylamino)-3-aryl-3-butene-2-one, ethyl-5-aryl-4-oxo-4H-pyran-2-carboxylate, ethyl-5-aryl-4-pyridones-2-carboxylate and 5-aryl-3-cyano-5-methyl-2-pyridones (aryl=3-thienyl, 2-furyl) are described.