The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl+ ++- (L)-D-alanyl-D-alanine disaccharide pentapeptide units into polymeric peptidoglycan. These units are phosphodiester linked, at C1 of muramic acid, to a C55 undecaprenyl carrier. PBP1b has b...

BACKGROUND The shortcomings of clonazepam therapy include tolerance, withdrawal symptoms, and adverse effects such as drowsiness, dizziness, and confusion leading to increased risk of falls. Inter-individual variability in the incidence of adverse events in patients partly originates from the differences in clonazepam metabolism due to genetic and nongenetic factors. METHODS Since the promine...

Extracts from HeLa cells treated with excess diphtheria toxin for several hours, until all protein synthesis has been arrested, are still able to stimulate the poly U-directed incorporation of phenylalanine into polypeptides at a moderate rate. Activity may be restored to normal levels or above by addition of a soluble enzyme fraction containing transferase II. Our results are in agreement with...

the toxicity of chlorpyrifos to three iranian populations of two-spotted spider mite, collected from isfahan (isr), yazd (yz) and guilan (gus2) provinces were surveyed using the residual contact vial bioassay. the bioassay results showed that resistance ratios of isr and yz populations were 176.90 and 9.78 fold compared to the gus2 population, respectively. determination of esterase and glutath...

the objective of this experiment was to determine the effect of long-term low-dose administration of lead (pb) on thyroid function in sheep. in this experiment 10 healthy iranian male sheep, aged about oneyear- old were randomly allocated into two equal groups of control (n = 5) and experiment (n = 5). both groups were kept under the same conditions of food and environment. the treatment group ...

he objective of the present study was to evaluate the effect of abamectin on liver function of rats. Abamectin is used as antiparasitic drug in agricultural and domestic animals. Sixty adult male albino rats (150±10g) were classified into 3 groups: Group (1), Control group given tap water; Group (II) Sub-acute group orally treated with 2 /3 LD50 of abamectin (9.83 mg/kg b.w) for 21 days (4 dose...

Endoxyloglucan transferase is a novel class of glycosyltransferase recently purified from Vigna angularis (Nishitani, K,, and Tominaga, R. (1992) J. Biol. Chem. 267, 21058-21064). This enzyme is the first transferase identified that catalyzes molecular grafting between polysaccharide cross-links in the cell wall matrix and participates in reconstruction of the network structure in the cell wall...

This study investigated the therapeutic effects of Vernonia amygdalina aqueous leaf extract administration on Salmonella typhimurium infected Wistar rats. Rats were orally by a single dose (1.5 x 108 CFU). Negative control groups and treated with vehicle (distilled water), neutral group not infected, while four test up to 24 days 50 mg/kg. 100 mg/kg, 150 mg/kg 200 body weight V. respectively. T...

Metabolic changes, principally in intermediary metabolism and nitrogen excretion, were investigated in the marble swamp eel (Synbranchus marmoratus) after 15 and 45 days of artificially induced semi-aestivation. Glucose, glycogen, lactate, pyruvate, free amino acids, triglycerides, ammonia, urea, and urate contents were determined in liver, kidney, white muscle, heart, brain, and plasma. Lactat...

In this study, our aim was to investigate whether cellular alterations occurred in liver and lung tissue in presence of chronic alcohol ingestion and Pseudomonas aeruginosa pneumonia related to oxidative stress and in situ cell death. Male wistar rats were divided into five groups: the sham group fed by normal solid diet, two control groups; one fed by normal liquid diet, and the other fed by l...