BACKGROUND Patients with cystic fibrosis (CF) can become colonized by aspergillus, which can act as an allergen and cause allergic bronchopulmonary aspergillosis (ABPA). OBJECTIVE To determine the rate of aspergillus colonization and ABPA in a population of Irish patients with CF. METHODS In 50 consecutive patients with CF who presented with exacerbations, we looked for the presence of aspe...

Objective: To determine if patients with bronchiectasis and non-tuberculous mycobacteria (NTM) have a higher prevalence of aspergillus-related lung disease. Methods: A series of 30 consecutive patients with bronchiectasis and NTM (cases) were compared with 61 patients with bronchiectasis and no evidence of NTM (controls). Aspergillus serology and computerised tomography (CT) of thorax were used...

Aspergillus oryzae has been used in the food and beverage industry for centuries, and industrial strains have been produced by multiple rounds of selection. Targeted gene deletion technology is particularly useful for strain improvement in such strains, particularly when they do not have a well-characterized meiotic cycle. Phenotypes of an Aspergillus nidulans strain null for the CreB deubiquit...

Microbial transformation can strengthen the antioxidant and antitumor activities of polyphenols. Polyphenols contents, antioxidant and antitumor activities of pine polyphenols and its biotransformation extracts by Aspergillus niger, Aspergillus oryzae, Aspergillus carbonarius, Aspergillus candidus, Trichodermas viride, Mucor wutungkiao and Rhizopus sp were studied. Significant differences were ...

PURPOSE To establish polyhexamethylene biguanide (PHMB) as an effective treatment for Aspergillus keratitis in a novel murine model. To determine the ability of the calcineurin inhibitors tacrolimus (FK506) and cyclosporine A (CSA) to enhance the activity of PHMB, amphotericin B (AMB), and voriconazole (VCZ) against Aspergillus keratitis. METHODS IN VITRO STUDIES Broth antifungal susceptib...

STUDY OBJECTIVE To determine the relationship between aspergillus recovery from the airways of lung transplant recipients and the development of endobronchial abnormalities. DESIGN Retrospective case series. SETTING Tertiary-care hospital. PATIENTS All patients who underwent lung transplantation between December 1991 and June 1999. MEASUREMENTS AND RESULTS The study cohort included 38 p...

background: aspergillus species are associated with allergic bronchopulmonary disease, mycotic keratitis, otomycosis, na­sal sinusitis and invasive infection. in this study, we developed a pcr-single strand confomational polymorphism method to identify the most common aspergillus species and we showed some advantages of this method comparing a pcr-restric­tion fragment length polymorphism with ...

a 46- year–old man with pulmonary tuberculosis which had treated with ant tuberculosis drugs was referred to medical mycology laboratory, school of public health and institute of public health research for coughing and bloody sputum. chest x-ray revealed a cavern with a moveable mass in right apical lobe. direct examination of sputum showed wide septated dichotomous hyphae and aspergillus fumig...

background: introduction of the rna interference (rnai) machinery has guided the researchers to discover the function of essential vital or virulence factor genes in the microorganisms such as fungi. in the filamentous fungus aspergillus nidulans, the gene sidb plays an essential role in septation, conidiation and vegetative hyphal growth. in the present study, we benefited from the rnai strate...