John Snow’s work on resuscitation is less well known than his contributions to the scientific foundations of anaesthesia [1]. However, together with his understanding of the physiopathology of respiration, it was not the least of the reasons for his fundamental contributions to anaesthesia. His initial work on resuscitation with asphyxiated stillborn infants, was published in 1841 [2], but, as ...

Ectopia cordis is a rare congenital defect in which the heart is displaced partially or completely, out of the chest. We present a case of term male neonate, delivered by elective caesarean section, asphyxiated and transferred to neonatal intensive unit at one hour of age. The baby had thoracic ectopia cordis and gastroschisis. The baby was unstable, cyanosed, required vasopressors and ventilat...

We describe an unexplained case of umbilical cord segmental hemorrhage linked with meconium-stained amniotic fluid. A severely asphyxiated infant was delivered at term by Caesarean section. There were poor prognostic signs on fetal cardiotocography with rupture of membranes with meconium-stained amniotic fluid. The pathophysiologic mechanism in this case is still unknown, even if we argued a po...

BACKGROUND AND PURPOSE MR imaging has been shown to be of prognostic significance in the evaluation of asphyxiated neonates. The purpose of this project was to determine whether the use of intensity ratios in key regions of the brain might better detect regions of injured brain and thus improve the correlation of imaging findings with 12-month neurodevelopmental outcome. METHODS Prospectively...

BACKGROUND Optimizing resuscitation is important to prevent morbidity and mortality from perinatal asphyxia. The metabolism of cells and tissues is severely disturbed during asphyxia and resuscitation, and metabolomic analyses provide a snapshot of many small molecular weight metabolites in body fluids or tissues. In this study metabolomics profiles were studied in newborn pigs that were asphyx...

The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM-1),...

neonatal respiratory distress is a very common problem in our practice. the causes may be respiratory, cardiovascular, central, metabolic, haematological and surgical. the cause of distress due to transient myocardial depression is not very common in mild asphyxia. we present a case having transient myocardial depression with severe respiratory distress and features of shock in a mild asphyxiat...