Early recognition of patients at high risk of acute lung injury (ALI) is critical for successful enrollment of patients in prevention strategies for this devastating syndrome. We aimed to develop and prospectively validate an ALI prediction score in a population-based sample of patients at risk. In a retrospective derivation cohort, predisposing conditions for ALI were identified at the time of...

Acute lung injury (ALI) remains a major cause of morbidity and mortality in critically ill patients. Despite improved understanding of the pathogenesis of ALI, supportive care with a lung protective strategy of mechanical ventilation remains the only treatment with a proven survival advantage. Most clinical trials in ALI have targeted mechanically ventilated patients. Past trials of pharmacolog...

Acute lung injury (ALI) is a critical illness syndrome with a mortality rate of 25-40%. Despite recent advances of our understanding of the pathophysiology of ALI, no pharmacologic therapies have been proven effective. The key pathogenesis of ALI is the activation of the coagulation cascade and impaired fibrinolysis, resulting in extensive fibrin and hyaline membrane deposition. Activated prote...

Machine learning algorithms for controlling devices will need to learn quickly, with few trials. Such a goal can be attained with concepts borrowed from continental philosophy and formalized using tools from the mathematical theory of categories. Illustrations of this approach are presented on a cyberphysical system: the slot car game, and also on Atari 2600 games.

In 1983, the videogame market in the USA collapsed, leading to bankruptcy for more than 90 percent of game developers, as well as Atari, manufacturer of the dominant game console at the time. The main reason was a ‘lemons’ market failure: because it had not developed a technology for locking out unauthorized games, Atari was unable to prevent the entry of opportunistic developers, who flooded t...

according adhar bigdili, muhammad ali was son of abdal biq naqqashbashi (painter laureate)and grandson of aliquli biq jabadar, court painter of shah safi and shah abbas ii safawi. adhar bigdili credited muhammad ali with naqqashbashi of shah tahmasp ii safawi and nadir shah afshar. having learnt the art of painting from his father, muhamma ali in turn trained ali ashraf, who worked under patron...