PURPOSE The Notch signaling pathway is widely expressed in normal, reactive, and neoplastic tissues; however, its role in thyroid tissues has not been fully elucidated. Therefore, this study was conducted to characterize the expression of the Notch signaling pathway in papillary thyroid cancer (PTC) cells and anaplastic thyroid cancer (ATC) cells. MATERIALS AND METHODS Expression of activated...

OBJECTIVE To compare performance of flow-adapted compensation of endotracheal tube resistance (automatic tube compensation, ATC) between the original ATC system and ATC systems incorporated in commercially available ventilators. DESIGN Bench study. SETTING University research laboratory. SUBJECTS The original ATC system, Dräger Evita 2 prototype, Dräger Evita 4, Puritan-Bennett 840. INT...

OBJECTIVE To discuss the current resuscitative strategies for trauma-induced hemorrhagic shock and acute traumatic coagulopathy (ATC). ETIOLOGY Hemorrhagic shock can be acutely fatal if not immediately and appropriately treated. The primary tenets of hemorrhagic shock resuscitation are to arrest hemorrhage and restore the effective circulating volume. Large volumes of isotonic crystalloids ha...

A method of calculating Available Transfer Capability (ATC) and the exploration of the relative effects of certain computational issues are described in this paper. Specifically, the calculation of ATC is laid out for the purposes of pointing out the various computational aspects that affect it such as algorithmic tolerances and source/sink composition among others. Test cases from the Pennsylv...

Molecular pathways regulating rapid proliferation and persistence are fundamental for pathogens but are not elucidated fully in Toxoplasma gondii. Promoters of T. gondii ribosomal proteins (RPs) were analyzed by EMSAs and ChIP. One RP promoter domain, known to bind an Apetela 2, bound to nuclear extract proteins. Promoter domains appeared to associate with histone acetyl transferases. To study ...

OBJECTIVE This study aimed to evaluate if the combination of pressure-support ventilation (PSV) and automatic tube compensation (ATC) is superior to PSV alone in weaning patients with severe neurotoxic snake envenoming receiving mechanical ventilation. METHODS Forty-one patients on volume controlled continuous mandatory ventilation were randomized to weaning with PSV alone (PSV group, 18 pati...

PURPOSE Cancer immunotherapy has been limited by anergy of patient T cells, inadequate numbers of precursor tumor-specific CTL, and difficulty in producing therapeutic doses of CTL. To overcome these limitations, bispecific antibodies have been used to create artificial antibody receptors that direct polyclonal activated T cells (ATC) to target tumor antigens. Studies reported herein were desig...

Cancer stem cells (CSCs) are expanded in anaplastic thyroid cancer (ATC) and standard treatment approaches have failed to improve survival, suggesting a need to specifically target the CSC population. Recent studies in breast and colorectal cancer demonstrated that inhibition of the SUMO pathway repressed CD44 and cleared the CSC population, mediated through SUMO-unconjugated TFAP2A. We sought ...

Anaplastic thyroid carcinomas (ATC) are undifferentiated tumors that show rapid progression and dissemination. The recent increase in knowledge about cancer stem cells has attracted marked interest in ATC, since these lesions are suggested to be closely related to thyroid stem cells (TSCs). Due to the rarity of ATCs, however, the gene expression patterns that characterize these lesions have not...

INTRODUCTION Bispecific antibodies (BiAbs) are used to enhance targeting of T cells and other cytotoxic agents to tumors while minimizing non-specific tissue toxicities. This study compares the targeting efficacy of 3 BiAbs derived from chemically heteroconjugating a T cell-directed monoclonal antibody (mAb) to 9184, 9187 or 9189, which are mAbs directed at extracellular antigens expressed on h...