UNLABELLED Adenoid, nasal and middle ear diseases are frequent health problems for young children. Allergic diseases of the upper respiratory tract are becoming one of the leading factors in the etiology of Eustachian tube dysfunctions and this dysfunction is the most significant etiologic factor of secretory otitis (OMS). To examine the influence of atopy on the OMS we studied 89 children ages...

After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped fo...

OBJECTIVES Nasal polyposis has a great impact on the quality of life. The aim of this study was to evaluate the association between quality of life and atopy, sinus opacification, and nasal patency in severe nasal polyposis. METHODS One hundred nine patients completed the Medical Outcome Study Short Form-36 (SF-36) survey. Symptoms, polyp size, atopy, nasal patency, and sinus opacification we...

Atopy is a major risk factor for the development of asthma. Immune processes that lead to the development of antigen-specific IgE are essential to the development of atopy. This review examines the immune processes that are candidate targets for modulation by environmental agents; environmental and lifestyle factors that have been suggested as modulators of the development of atopy; and the imp...

BACKGROUND There is a big contradiction in the medical literature regarding the relationship between atopy and contact hypersensitivity. Some researchers believe that atopy would prevent, whereas others believe that it would promote, the development of contact allergy. Possible causes of this confusion range from different study populations to different definitions of atopy. OBJECTIVE To eval...

The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom; Stochastic Systems Group, Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, Massachusetts; Microsoft Research Cambridge, Ca...

OBJECTIVE To assess whether children with history of infantile colic may be at increased risk of subsequently developing asthma and/or atopy. METHODS We used data collected in a large, prospective study from an unselected population. Infantile colic and concurrent feeding method were determined from the 2-month well-infant visit form completed by the physician for 983 children who were enroll...

Clear sex differences exist in asthma and atopy with a preponderance of boys before puberty. There is a reversal of this sex ratio during puberty with girls having more asthma and atopy throughout the reproductive years. Elucidating the reasons for the switch in the sex ratio should provide fresh insights into asthma and atopy with a real prospect of novel therapies for these troublesome diseas...

The aim of study was to evaluate various risk in patients who were hospitalized with moderate to severe virus-induced wheezing. Infants hospitalized with virus-induced wheezing were enrolled in the study. Respiratory viruses were detected in nasopharyngeal swab and total IgE levels and skin prick tests were performed in all patients. The mean age of the patients was 11.2±9 months. The most comm...