BACKGROUND Muscle atrophy impacts almost every patient seen for orthopaedic conditions. Unfortunately, no effective treatment is available to date. Matrix metalloproteinases (MMPs), especially MMP-2, are involved in skeletal muscle atrophy. MMP-2 null mice reportedly have substantially reduced muscle atrophy after tendon transection compared with wild-type mice, suggesting MMP-2 plays an import...

PURPOSE To characterize atrophy of the outer retina and the retinal pigment epithelium in patients with pseudoxanthoma elasticum (PXE). METHODS In this retrospective cross-sectional study, the frequency and phenotypic characteristics of manifest atrophy were investigated in 276 eyes of 139 patients using color fundus photography, fundus autofluorescence (AF) imaging, and spectral domain optic...

Brain lesions due to leucine-rich glioma-inactivated 1 (LGI1)-antibody encephalitis are usually limited to the medial temporal lobe, including the abnormal signal and variable degrees of atrophy. Cases of diffuse cerebral atrophy subsequent to LGI1-antibody encephalitis are rare. Here we report a 74-year-old male patient who developed LGI1-antibody encephalitis, and subsequently with rapid and ...

This report describes a young woman with ulcerative colitis who developed rapidly fatal pneumococcal septicaemia. Necropsy revealed splenic atrophy. This case supports the hypothesis that splenic atrophy might contribute to the morbidity of ulcerative colitis. The occurrence of splenic atrophy in ulcerative colitis is now well established. Splenic atrophy from other causes has been associated w...

Background: Hippocampal atrophy on MRI is an early characteristic of Alzheimer’s disease (AD). However, hippocampal atrophy may also occur in other dementias, like frontotemporal lobar degeneration (FTLD). Aim: To investigate hippocampal atrophy on MRI in FTLD and its three clinical subtypes, in comparison to AD, using volumetry and a visual rating scale. Methods: Forty-two patients with FTLD (...

Purpose To evaluate the development of central atrophy in eyes with age-related macular degeneration (AMD). Methods Six-year longitudinal multimodal retinal imaging data (MODIAMD study) from 98 eyes of 98 subjects with non-late-stage AMD in the study eye at baseline were analyzed for the presence of central atrophy at each annual follow-up visit. Development, manifestation, and further progre...