We use evolutionary computation techniques to create real-time reactive controllers for a race-car simulation game: RARS (Robot Auto Racing Simulator). Using genetic programming to evolve driver controllers, we create highly generalized game-playing agents, able to outperform most human-crafted controllers and all machine-designed ones on a variety of game tracks.

Probiotics are live bacteria that confer health benefits to the host physiology. Although protective role of probiotics have been reported in diverse diseases, no information is available whether probiotics can modulate neuromuscular immune disorders. We have recently demonstrated that IRT5 probiotics, a mixture of 5 probiotics, could suppress diverse experimental disorders in mice model. In th...

Leprosy patients, including those with various clinical forms, present widely disseminated lesions in tissues and organs, of diverse histopathology. These lesions are present in skin and mucosa, peripheral nerves, organs, vessels, muscles, bones, etc. According to the clinical form, lesions vary-in characteristic, borderline, tuberculoid and lepromatous-and, in general, are inflmmatory or degen...

BACKGROUND Gastric parietal cells in a baboon were recently found to be auto-fluorescent. AIM To study gastric sections with a fluorescent microscope in a cohort of baboons. MATERIAL AND METHODS Gastric sections from 38 baboons were stained with hematoxylin-eosin (H&E) and examined in a fluorescence microscope (FLM). The thickness of the parietal cell population was assessed at x 10 magnifi...

Introduction: Multiple sclerosis (MS) has been recognized as a common neurodegenerative disease that occurs after an Auto reactive T cells against myelin antigens.  Demyelination and inflammation are the main features of this disease. The anti-inflammatory and neuroprotective roles of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been considered as a suitable tre...

IMPORTANCE Stiff person syndrome (SPS) is a rare neurological disease causing significant functional disability for patients and presenting a therapeutic challenge for clinicians. Autologous hematopoietic stem cell transplantation (auto-HSCT) has been used successfully to remit autoimmune-mediated neurological diseases. We report 2 cases of severe SPS treated with auto-HSCT, a novel therapy for...

The. inbred NZB/BL mouse has been shown by Bielschowsky, Helyer, and Howie (1959) to develop auto-immune haemolytic anaemia spontaneously, and this disorder has been considered to be genetically determined (Holmes and Burnet, 1966). Burnet and Holmes (1962) described a characteristic thymic change in this 'auto-immune' strain of mice; and certain renal lesions have been noted (Holmes and Burnet...

The. inbred NZB/BL mouse has been shown by Bielschowsky, Helyer, and Howie (1959) to develop auto-immune haemolytic anaemia spontaneously, and this disorder has been considered to be genetically determined (Holmes and Burnet, 1966). Burnet and Holmes (1962) described a characteristic thymic change in this 'auto-immune' strain of mice; and certain renal lesions have been noted (Holmes and Burnet...

Malignant melanoma is one of the most aggressive types of tumor. Because malignant melanoma is difficult to treat once it has metastasized, early detection and treatment are essential. The search for reliable biomarkers of early-stage melanoma, therefore, has received much attention. By using a novel method of screening tumor antigens and their auto-antibodies, we identified bullous pemphigoid ...

Purpose The purpose of this paper is to highlight the ways in which reactive researcher collaboration helps manage some challenges present insider research. Design/methodology/approach Employing (auto)biographical reflections from across two different case-studies, authors explore enmeshed with issues associated researching familiar a marketized university environment. Findings develop term “re...