Unrepaired DNA double-strand breaks can lead to apoptosis or tumorigenesis. In mammals double-strand breaks are repaired mainly by nonhomologous end-joining mediated by the DNA-PK complex. The core protein of this complex, DNA-PKcs, is a DNA-dependent serine/threonine kinase that phosphorylates protein targets as well as itself. Although the (auto)phosphorylation activity has been shown to be e...

INTRODUCTION: Physiologic shoulder motion is dependent on a complex balance of forces. In particular, the anterior-posterior (AP) force balance in the shoulder is primarily comprised of the subscapularis and infraspinatus-teres minor complex of the rotator cuff [1]. Massive chronic rotator cuff tears, a common clinical problem, can disrupt this balance and present a management challenge. Moreov...

this paper investigates the lateral vibration of single-layered graphene sheets based on a new theory called doublet mechanics with a length scale parameter. after a brief reviewing of doublet mechanics fundamentals, a sixth order partial differential equation that governs the lateral vibration of single-layered graphene sheets is derived. using doublet mechanics, the relation between natural f...

BACKGROUND Radial transection of the peripheral fibers of the meniscus could render it nonfunctional; however, the biomechanical consequences of a complete lateral meniscal radial tear and repair in human specimens have not been elucidated. HYPOTHESIS A complete radial tear will exhibit knee contact mechanics approaching those of total meniscectomy. Repair of complete radial tears will re-cre...

Thomas Karcher Institute for Program Structures and Data Organization Karlsruhe Institute of Technology 76128 Karlsruhe, Germany [email protected] Christopher Guckes Institute for Program Structures and Data Organization Karlsruhe Institute of Technology 76128 Karlsruhe, Germany [email protected] Walter F. Tichy Institute for Program Structures and Data Organization Karlsruhe Institute...

Service-oriented architectures (SOA) and, in particular, Web Services designs are widely adopted for the development of interoperable systems. In a dynamic scenario, a composed service may exploit component services in order to complete its task; composed services are variously distributed, and offered by different providers in different security domains and under different load conditions. So,...