Using two different kinds of monoclonal autoantibodies, anti-mouse RBC (MRBC) autoantibodies and IgG3 rheumatoid factor (RF) cryoglobulins, we have attempted to better define the molecular and cellular basis of the pathogenicity of autoantibodies. Among eight anti-MRBC monoclonal antibodies (mAbs) obtained from NZB mice, only five of them are able to cause anemia. The distinct differences in sp...

background & objective: autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. the tissue-bound and circulating serum autoantibodies can be detected wi...

Detection and characterization of autoantibodies reacting with self-antigens is generally used in laboratory diagnostics. However, the presence of different autoantibodies in the blood serum doesn’t mean automatically a pathologic condition. Autoantibodies are present both in different diseases as autoimmune diseases, chronic inflammation or infections, and in healthy individuals without any sy...

BACKGROUND Pre-eclampsia is the leading cause of maternal and neonatal morbidity and mortality with incompletely understood etiopathogenesis. The purpose of the current study is to determine whether there is a relationship between the presence of autoantibodies against β1, β2 and α1 adrenoreceptors and severe pre-eclampsia. METHODOLOGY/PRINCIPAL FINDINGS Synthetic peptides corresponding to am...

1.1 The B-cell response in autoimmune disease1 The pathological effects of autoimmune diseases on the target tissues can be mediated by autoantibodies, cell-mediated immune responses, or both. It is increasingly evident that some autoimmune diseases previously thought to be essentially T-cell-mediated also have a B-cell component, which may involve direct effects of autoantibody secreted by pla...

anti-neutrophil cytoplasmic autoantibodies have been detected in patients with some autoimmune and vascular diseases such as wegner's granulomatosis, polyarthritis nodosa and systemic lupus erythematosus. indirect immunofluorescence technique has been employed to detect these autoantibodies. by this method, two general patterns of antineutrophil cytoplasmic antibodies were seen: a cytoplasmic (...

BACKGROUND Chronic hepatitis C virus (HCV) is associated with extra hepatic autoimmune disorders, while peg-IFNa-2a/RBV combination therapy may exacerbate these conditions. Autoantibodies to cytoplasmic structures, called rod and ring particles (RR), have strong associations with these patients and are identified by HEp-2 cells. OBJECTIVES Our purpose was to study the correlation of autoantib...

AIMS To examine a large series of patients in whom both red cell autoantibodies and carcinoma are present; and to determine whether this rare occurrence is a true association or a chance event. METHODS The laboratory records of 160 patients (76 men, 84 women; mean age 68 years) with erythrocyte autoantibodies and confirmed carcinoma were examined for site of tumour origin and clinical and imm...