Vaccinated and non-vaccinated specified pathogen-free White Leghorn laying chickens were challenged at peak of lay by the intravenous or oculonasal route with a virulent avian metapneumovirus (aMPV) subtype B chicken strain. Severe clinical signs and a drop in egg production were induced in the non-vaccinated intravenously challenged birds whereas the vaccinates were not affected. Live virus ex...

In 2001, human metapneumovirus (hMPV) was discovered in young children with respiratory tract infection of unknown origin. In the two years since its discovery the dinical characteristics of this new virus have been darified. In children, especially those younger than one year of age, hMPV is responsible for 5 to 10% of respiratory tract infections requiring hospitalisation; its clinical course...

Subtype C avian metapneumovirus (aMPV-C), is an important pathogen that can cause egg-drop and acute respiratory diseases in poultry. To date, aMPV-C infection has not been documented in Muscovy ducks in China. Here, we isolated and characterized an aMPV-C, designated S-01, which has caused severe respiratory disease and noticeable egg drop in Muscovy duck flocks in south China since 2010. Elec...

Avian Metapneumovirus (aMPV) affects both turkeys and chickens. The virus is associated with swollen head syndrome (SHS) in broilers. Most of the studies regarding aMPV have been done in turkeys. Not much is known about the pathogenesis and immune response to aMPV in broilers. Therefore, our objectives were to study the pathogenesis and immune responses of broilers experimentally infected with ...

Avian pneumovirus (APV) is a member of the genus Metapneumovirus of the subfamily Pneumovirinae. This study describes the development of a reverse-genetics system for APV. A minigenome system was used to optimize the expression of the nucleoprotein, phosphoprotein, M2 and large polymerase proteins when transfected into Vero cells under the control of the bacteriophage T7 promoter. Subsequently,...

PURPOSE OF REVIEW Recently, several previously unrecognized respiratory viral pathogens have been identified and several influenza A virus subtypes, previously known to infect poultry and wild birds, were transmitted to humans. Here we review the recent literature on these respiratory viruses. RECENT FINDINGS Human metapneumovirus has now been detected worldwide, causing severe respiratory tr...

BACKGROUND Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. METHODS During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5 years to identify those children who were hospitalized or who ...

results among the 158 children evaluated in this study, 49 individuals (31.1%) had rsv infection while nine individuals (5.7%) had hmpv infection. five (55.5%) of the hmpv-infected children were male while four (44.5%) were female and 27 (55.2%) of the rsv-infected patients were females and 22 (44.8%) were males. the rsv infections were detected in mainly < one year old children and hmpv infect...