Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key strategy for the development of new drugs. The activation of cellular stress responses mediated by the endoplasmic reticulum (ER) allows cancer cells to survive outside their normal environment. Many proteins that protect cells against ER stress are active as protein disulfide isomerases (PDI) and the aim...

Background: Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. Objective: To evaluate the prevalence of Staphyl...

It has now been firmly established by several groups of workers (1-10) that in yeast thiamine is enzymatically synthesized from pyrimidine pyrophosphate and thiazole monophosphate. However, there is little information about the biosynthetic pathways of pyrimidine and thiazole themselves. Thiamine was found as the first natural com pound containing a thiazole ring. Recently, the presence of the ...

TO THE EDITOR—Intestinal colonization with vancomycin-resistant Enterococcus faecium (VRE) is considered the major risk factor for VRE infection and transmission. Bacitracin was previously shown to decrease VRE colonization burden during its administration. Here, we describe a neutropenic patient with VRE bacteremia, which persisted despite multiple combination therapies until decolonization wa...

Abstract Antibiotics/feed additives are commonly used in poultry rations to prevent disease, increase feed efficiency, and improve performance. Plants the alternatives replace antibiotics that safe without side effects for chicken meat consumers. The aim of this study was evaluate effect administration a mixture plant powder Anacardium occidentale shell liquid smoke on total bacteria Escherichi...

The practice of breast-pocket irrigation with various antibiotic solutions is supported by good literature and extensive clinical practice among most plastic surgeons. Unfortunately, recent restrictions on the use of Betadine (povidone-iodine) for breast-pocket irrigation have left many plastic surgeons confused regarding their surgical protocol for aesthetic and reconstructive breast surgery. ...

The contribution of microbial amino acids through caecotrophy to tissue protein metabolism was investigated in lactating does. Attempts were made to vary microbial supply through a dietary antibiotic, Zn bacitracin, and to vary tissue demand through manipulation of litter size. Three groups of eight New Zealand does were fed different experimental diets from day 28 of pregnancy to day 26 of lac...

To combat antibiotic resistance of Enterococcus faecalis, a better understanding of the molecular mechanisms, particularly of antibiotic detection, signal transduction and gene regulation is needed. Because molecular studies in this bacterium can be challenging, we aimed at exploiting the genetically highly tractable Gram-positive model organism Bacillus subtilis as a heterologous host. Two fun...

Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key strategy for the development of new drugs. The activation of cellular stress responses mediated by the endoplasmic reticulum (ER) allows cancer cells to survive outside their normal environment. Many proteins that protect cells against ER stress are active as protein disulfide isomerases (PDI) and the aim...

The present study was conducted to investigate the effects of Clostridium butyricum inclusion, as an alternative for antibiotic, on growth performance, immunity and oxidative status of Cherry Valley ducks. 240 1-day-old Cherry Valley ducks were randomly allocated to 2 groups with 6 replicates of 20ducks, receiving a basal diet supplemented with zinc bacitracin (40 mg/kg diet, Control group) or ...