Recognition of virally infected cells by CD8+ T cells requires differentiation between self and nonself peptide-class I major histocompatibility complexes (pMHC). Recognition of foreign pMHC by host T cells is a major factor in the rejection of transplanted organs from the same species (allotransplant) or different species (xenotransplant). AHIII12.2 is a murine T cell clone that recognizes the...

This study sought to characterize the effect of density stress on greater amberjack ( Seriola dumerili ) survival determine an optimal transport density. To achieve this, this experiment simulated conditions fish (body length: 4.09 ± 1.00 cm; weight: 0.9 0.05 g) using closed oxygen at 5 different densities (D1 = 1.125 kg/m 3 , D2 2.25 D3 3.375 D4 4.5 and D5 6.75 for 8 hours, after which biochem...

Conventional major histocompatibility complex (MHC) class I genes encode molecules that present intracellular peptide antigens to T cells. They are ubiquitously expressed and regulated by interferon gamma. Two highly divergent human MHC class I genes, MICA and MICB, are regulated by promoter heat shock elements similar to those of HSP70 genes. MICA encodes a cell surface glycoprotein, which is ...

Small cell lung cancer (SCLC) is a highly aggressive tumor with early primary resistance and modest clinical response to immune checkpoint blockade (ICB). Mutations or transcriptional repression of the major histocompatibility complex class I (MHC-I) represent key mechanism driving T cell-based therapies. Lysine-specific demethylase 1 (LSD1) regulates gene expression via demethylating lysines 4...

Long-distance migratory animals such as birds and bats have evolved to withstand selection imposed by pathogens across the globe, pathogen richness is known be particularly high in tropical regions. Immune genes, so-called Major Histocompatibility Complex (MHC) are highly duplicated songbirds compared other vertebrates, this MHC diversity has been hypothesised result a unique adaptive immunity....

The major histocompatibility complex (MHC) contains many genes that play key roles in initiating and regulating immune responses. This includes the polymorphic MHCI MHCII present epitopes to CD8+ CD4+ T-cells, respectively. Consequently, characterisation of repertoire MHC is an important component improving our understanding genetic variation determines outcomes In cattle, (BoLA) research has p...

Abbreviations: MHC I: Major Histocompatibility Complex-Class I; MHC I : Major Histocompatibility Complex-Class II; PSSM: Position Specific Scoring Matrices; SVM: Support Vector Machine; GWD: Guinea worm disease; UniProt: The Universal Protein Resource; NCBI: National Center for Biotechnology Information; TAP: Transporter Associated with Antigen Processing; HPLC: High Performance Liquid Chromato...

Bovine theileriosis is a tick-borne disease caused by obligate intracellular parasites related to the genus Theileria. Cellular immune responses protect cattle against pathogens through the activation of immune cells. Nowadays, live, attenuated vaccine of Theileria annulata (T. annulata) is being produced in Iran and is recommended for active cattle immunization. Detection of the immunogenic  a...