The increasing prevalence of environmental pollution, especially soil contamination with heavy metals has led to their uptake in the human food chains through plant parts. Accumulation and magnification of heavy metals in human tissues through consumption of herbal remedies can cause hazardous impacts on health. Therefore, chemical profiling of nine heavy metals (Mn, Cr, Pb, Fe, Cd, Co, Zn, Ni ...

In the present communication, we have investigated effects of the CDRI-08, a well characterized extract of Bacopa monnieri, on expression of the GluN2B subunit of NMDAR in various brain regions of the scopolamine-induced amnesic mice. Our behavioral data reveal that scopolamine-treated amnesic mice exhibit significant decline in the spatial memory compared to the normal control mice. Our RT-PCR...

The aim of the present study is to investigate the effect of standardized extract of Bacopa monnieri (memory enhancer) and Melatonin (an antioxidant) on nuclear factor erythroid 2 related factor 2 (Nrf2) pathway in Okadaic acid induced memory impaired rats. OKA (200 ng) was administered intracerebroventricularly (ICV) to induce memory impairment in rats. Bacopa monnieri (BM-40 and 80 mg/kg) and...

There are varieties of traditional medicinal plants widely used for boosting memory. These include Bacopa monnieri, Rhodiola rosea, Ginkgo biloba, Withania somnifera, etc. Memory effect such is solely attributed to their active phytoconstituents. constituents also referred as smart drugs. capable crossing blood brain barriers. They enhance the cognitive performance in by acting on memory make i...

Current study aspire is to investigate the neuroprotective role of Bacopa monniera on MAO in AD induced mice with particular reference to Morphometric and Behavioural aspects. Mus musculus of one month old weighing 20±2gms, were used as experimental model and were maintained according to ethical guidelines for animal protection and welfare. Mice were divided in to four groups as follows: Group ...

The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...