background and objectives:  the most common problems limiting the medical use of aminoglycosides have been the nephro- and oto-toxicities as well as the increasing bacterial resistance. encapsulation of drugs into liposomes enhances their efficacy while reducing their toxicities. the aim of this study was to evaluate the antimicrobial activity of free and liposomal amikacin. material and method...

Biomimetic Photomodulable Bactericidal Nanozyme Exploration of bactericidal nanozymes with simultaneously high biofilm penetration and bacterial capture capacities is crucial yet challenging for combating infections. In article number 2301694, Guang Liang, Fangyuan Li, Daishun Ling, co-workers report a biomimetic photomodulable nanozyme dually enhanced capacities. Notably, the catalytic activit...

In the preceding paper (1), it was reported that rat leucocyfic extracts prepared by ultrasonic disintegration of polymorphonuclear neutrophils (leucocytes) were bactericidal against both Gram-negative and Gram-positive organisms. The bactericidal activity of these extracts was confined primarily to the mitochondria. The purpose of this report is to characterize this bactericidal substance or s...

Serious gram-negative bacterial infections (e.g. pneumonias caused by Escherichia coli, Hemophilus influenzae, and Klebsiella pneumoniae) are encountered with increased frequency in chronic alcoholics.`3 Normal human serum is bactericidal for many strains of gram-negative bacteria.'" A decrease in serum bactericidal activity might render the host more susceptible to infection caused by these or...

The global emergence of antibacterial resistance among common and atypical respiratory pathogens in the last decade necessitates the strategic application of antibacterial agents. The use of bactericidal rather than bacteriostatic agents as first-line therapy is recommended because the eradication of microorganisms serves to curtail, although not avoid, the development of bacterial resistance. ...

We conducted the following study to determine if bispecific antibodies enhance the bactericidal activity of bovine neutrophils. Bispecific antibodies were synthesized by chemically crosslinking bovine neutrophil monoclonal antibodies to Staphylococcus aureus 305 capsule polysaccharide monoclonal antibodies. The efficiency of chemically coupling monoclonal antibody monomers was approximately 50%...

Prior investigators have reported a broad gram-negative spectrum and a marked anti-Pseudomonas activity in vitro with BL-P1654, 6-[R-alpha-(guanylureido)phenylacetamido]-penicillanic acid. An in vitro comparison of BL-P1654 to carbenicillin was performed against 84 strains of Pseudomonas and 39 strains of Enterobacteriaceae. Mean minimal inhibitory concentrations in Mueller-Hinton broth of BL-P...

Granulocyte colony-stimulating factor (G-CSF) has important direct and priming effects on different functions of normal mature polymorphonuclear leukocytes (PMNL). Previous study has shown an alteration in respiratory burst and bactericidal activities of PMNL harvested from children with cancer treated with chemotherapy. The present study evaluates the possibility that recombinant human (rh) G-...

The acetaldehyde-xanthine oxidase system in the presence and absence of myeloperoxidase (MPO) and chloride has been employed as a model of the oxygen-dependent antimicrobial systems of the PMN. The unsupplemented xanthine oxidase system was bactericidal at relatively high acetaldehyde concentrations. The bactericidal activity was inhibited by superoxide dismutase (SOD), catalase, the hydroxyl r...

background: occupational exposure to cotton dust, fibers, metal fumes and different chemicals used in the apparel manufacturing industries cause a wide range of physical and psychological health problems in the garment workers that may also affect their immune function. objective: to assess the immune system function in garment workers. methods: a total of 45 workers of a garment factory, and 4...