helicobacter pylori :28 µg/ml).   (h. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. the most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or ...

in our previous study, we compared the two α-amylase enzymes from bacillus sp.kr8104, bka∆(n44) and bka∆(n44c193) which is the secreted form of it. the results indicated that the presence of 193 amino acids propeptide in the c-terminal of bka∆(n44) changed its enzymatic parameters like an uncompetitive inhibitor in comparison to bka∆(n44c193). in the present study, we cloned the dna sequence of...

copper amine oxidases (caos) catalyse the oxidative de-amination of biogenic amines which are ubiquitous compounds essential for cell growth and proliferation. the enzymes are homodimers containing both topaquinone and a cu(ii) ions as cofactors at the active site of each subunit. after extraction and purification of chickpea (cicer arietinum) amine oxidase by chromatoghraphy, km and vmax of th...

Septic infections dysregulate hemostatic pathways, prompting coagulopathy. Nevertheless, anticoagulant therapies typically fail to protect humans from septic pathology. The data reported in this work may help to explain this discrepancy by demonstrating critical protective roles for coagulation leading to fibrin deposition during host defense against the Gram-negative bacterium Yersinia enteroc...

Internalin B (InlB), a 630-amino acid protein loosely attached to the surface of Listeria monocytogenes, participates in the entry of the bacterium into mammalian cells. This process requires the activation of phosphoinositide (PI) 3-kinase by InlB. Previously, we demonstrated that InlB activates the transcription factor Nuclear FactorB in murine J774 macrophage-like cells, an event that also r...

melanin pigment plays a critical role in camouflage and   protection against harmful effects of solar radiation. melanogenesis is under   complex regulatory control by multiple agents. tyrosinase is a   multifunctional, which catalyzes the first two steps in mammalian   melanogenesis. in this study, inhibitory effects of astragalus fasciculifolius   and astragalus gypsicolus on diphenolase acti...

genistein is a soya isoflavone, which is found naturally in legumes, such as soybeans and chickpeas. the intraperitoneal administration of the optimum dose (200 mg/kg) of genistein 24 h and 15 minbefore irradiation (8 gy at a dose rate of 1.02 gy/min) recovered the deficit in protein content (28.63±1.44%) and the dna content (21.61±8.19%) if an average of 5 intervals of autopsies 1st, 3rd, 7th,...

sesame oil cake (ssc) was bio-processed through solid state fermentation (ssf) under optimized conditions by a phytase-producing fish gut bacterium, bacillus subtilis subsp. subtilis (jx292128). ssf significantly reduced anti-nutritional factors (e.g., phytic acid, tannins and trypsin inhibitor) and crude fibre, while enhanced free amino acids, fatty acids and different minerals. phytase product...

letrozole is a synthetic aromatase inhibitor and interfere in the committed step in the synthesis of endogenous estrogens from androgens. also estrogens regulate the immune system in teleost. changes of 17- β- esrtradiol (e 2 ), serum immunoglobulin and lysozyme levels were measured using a method based on the ability of lysozyme to lyse the bacterium micrococcus lysodeikticus , enzyme-linked i...

Enterohemorrhagic Escherichia coli O157: H7 is one of the most important causes of bloody diarrhea. This bacterium is able to make bloody diarrhea or Hemorrhagic Colitis (HC) through verotoxin or shigatoxin production, and in acute forms it may lead to Hemolytic Uremic Syndrome (HUS) or Thrombotic Thrombocytopenic Purpurea (TTP). Contamination with E. coli O157:H7 usually happens after consumpt...