Systemic lupus erythematosus (SLE or lupus) is a systemic autoimmune disease characterized by a constellation of varied clinical presentations, although the nearly universal presence of autoantibodies is a salient unifying feature. Ongoing research efforts focus on understanding the complex combination of genetic and environmental factors that lead to SLE in select individuals. Our previous wor...

A monoclonal antibody, referred to as 38.13, was obtained by fusing murine myeloma cells with Lewis rat splenocytes sensitized with Daudi cells (human Burkitt lymphoma containing Epstein--Barr virus genome but lacking HLA-A, -B, and -C and beta 2-microglobulin molecules at the cell surface). 38.13 antibody was demonstrated to be a rat IgM. By complement-dependent microcytotoxicity and indirect ...

ulcerative colitis (uc) is one type of inflammatory bowel disease (ibd). herpes viruses have been suggested as possible etiological agents of uc and crohn’s disease (cd). the aim of this study was to investigate the prevalence of herpes simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv) in patients with uc in comparison with healthy subjects by using pcr technique. in this ...

Pure human gamma-interferon as well as alpha-interferon inhibited induction of immunoglobulin synthesis by Epstein-Barr virus but not by pokeweed mitogen in B lymphocytes from adult but not from newborn humans. The interferons inhibited the infected B lymphocytes directly, irrespective of the Epstein-Barr virus immune status of the donor, and their inhibitory effect was synergistic.

Neurological complications of Epstein-Barr infection are rare though well recognised. Cerebrospinal fluid (CSF) abnormalities may occur in up to a quarter of infected patients. The nervous system may be affected in the absence of classical glandular fever infection. The following case illustrates some of the many effects of Esptein-Barr virus on the nervous system, including aseptic meningitis,...

INTRODUCTION We present a case of an unusual clinical manifestation of Guillain-Barre syndrome following a pre-existing herpes virus infection. Although there have been several reports describing the co-existence of herpes virus infection and Guillain-Barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serolo...

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epst...

Epstein-Barr virus-associated early antigen and viral capsid antigen were efficiently induced in human lymphoblastoid P3HR-1 cells with culture fluid of Fusobacterium nucleatum, a member of the indigenous microbial flora of the human host. This finding may suggest a new approach to assess the possible role of the "cofactor(s)" in the etiology of Epstein-Barr virus-related diseases.

Elevated liver enzymes accompanied by Infectious Mononucleosis syndrome are widely seen in primary Epstein-Barr virus infection while acute symptomatic hepatitis without typical presentations of EBV is extremely rare. In the following report, we present a patient with acute isolated hepatitis due to laboratory confirmed Epstein-Barr virus.