Branched-chain amino acids (BCAAs) are synthesized in plants from branched-chain keto acids, but their metabolism is not completely understood. The interface of BCAA metabolism lies with branched-chain aminotransferases (BCAT) that catalyze both the last anabolic step and the first catabolic step. In this study, six BCAT genes from the cultivated tomato (Solanum lycopersicum) were identified an...

Branched-chain amino acids (BCAAs) are often used for nutritional support in patients with decompensated liver cirrhosis. However, the effect of long-term oral supplementation with BCAAs on the onset and progression of hepatocellular carcinoma (HCC) in patients with chronic liver disease is unknown. We investigated the effect of long-term oral supplementation with BCAAs for a model of spontaneo...

Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited.Patients who were diagnosed with liver cirrhosis with a Child-Pugh (CP) score of 8-10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. We analyzed the improvements b...

Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked to altered adipose tissue BCAA catabolism. We tested the hypothesis that some features of this metabolite signature relate closely to visceral obesity and concomitant alterations in cardiometabolic risk factors. We also postulated that alt...

Exercise enhances branched-chain amino acid (BCAA) catabolism, and BCAA supplementation influences exercise metabolism. However, it remains controversial whether BCAA supplementation improves exercise endurance, and unknown whether the exercise endurance effect of BCAA supplementation requires catabolism of these amino acids. Therefore, we examined exercise capacity and intermediary metabolism ...

Current formulations for acute tryptophan (Trp) or tyrosine (Tyr) plus phenylalanine (Phe) depletion and loading cause undesirable decreases in ratios of Trp or Tyr + Phe to competing amino acids (CAA), thus undermining the specificities of these tests. Branched-chain amino acids (BCAA) cause these unintended decreases, and lowering their content in a new balanced control formulation in the pre...

We found an error in our paper recently published in Nutrients [1]. In our discussion of the Karlsson et al. 2004 paper published in the American Journal of Physiology [2], we failed to identify that the dose of branched-chain amino acids (BCAA) was calculated on the basis of body weight. These investigators provided the subjects a total of 100 mg BCAA/kg body weight, not a total ingested dose ...

The aim of the present study was to investigate the relationships between serum amino acid profiles in normal and calves with Mycoplasma bronchopneumonia. Serum free amino acid concentrations in serum obtained from 34 calves with or without Mycoplasma bronchopneumonia were determined by high-performance liquid chromatography. The calves with Mycoplasma were characterized by significantly lower ...

The branched chain amino acids (BCAA) valine, leucine and isoleucine have been implicated in a number of diseases including obesity, insulin resistance, and type 2 diabetes mellitus, although the mechanisms are still poorly understood. Adipose tissue plays an important role in BCAA homeostasis by actively metabolizing circulating BCAA. In this work, we have investigated the link between BCAA ca...

In recent years, a number of new functions branched-chain amino acids (BCAA) - leucine, valine and isoleucine have been revealed in various states the body animals humans. BCAA are involved regulation metabolism not only proteins, but also lipids carbohydrates, maintain health mammary glands intestines, help early implantation development embryos. increase protein synthesis currently considered...