BACKGROUND In Uganda, the tuberculosis vaccine BCG is administered on the first day of life. Infants delivered at home receive BCG vaccine at their first healthcare facility visit at 6 weeks of age. Our aim was to determine the effect of this delay in BCG vaccination on the induced immune response. METHODS We assessed CD4(+) and CD8(+) T-cell responses with a 12-hour whole-blood intracellular...

PURPOSE There are considerable variations in the number of adverse reaction reports related to vaccine from different countries. The aim of this study was to review the development of adverse reactions to bacille Calmette-Guérin (BCG) vaccination among hospitalized patients in an Iranian referral hospital. MATERIALS AND METHODS We identified hospitalized patients with BCG complications in Ped...

An audit of the selective neonatal BCG immunisation programme showed that only 51% of eligible infants received the vaccination. Infants of Indian subcontinental origin (ISC) were significantly more likely to have been vaccinated than non-ISC infants (ISC 70% v non-ISC 29%). Greater awareness of the eligibility of non-ISC infants for BCG as well as simplification of the eligibility criteria are...

BACKGROUND Over the past four decades, the World Health Organization established the Expanded Programme on Immunization (EPI) to foster universal access to all relevant vaccines for all children at risk. The success of this program has been undeniable, but requires periodic monitoring to ensure that coverage rates remain high. The aim of this study was to measure the BCG vaccination coverage in...

der the conditions of the trial , it could not be concluded that BCG had been effective in the prevention of leprosy, but that present results have suggested that BCG raises the level of general resistance to invasion by lvi . leprae, plays a role in the development of inapparent or self-healing forms , rather than the more severe forms of the disease, and prevents relapse of the self-healed ca...

Bacille Calmette-Guérin (BCG) vaccine exerts nonspecific immunostimulatory effects and may therefore represent a novel therapeutic option to treat sepsis-induced immunoparalysis. We investigated whether BCG vaccination modulates the systemic innate immune response in humans in vivo during experimental endotoxemia. We used inactivated gamma-irradiated BCG vaccine because of the potential risk of...

Secondary complications after Bacille Calmette-Guerin (BCG) vaccination are unusual. We describe 3 immunocompetent children who developed osteomyelitis after BCG vaccination. The course of the disease is not dramatic, but marked changes are frequently visible in plain radiograph and MRI. The real-time polymerase chain reaction has an essential role to confirm the diagnosis of BCG osteomyelitis....

The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. beneficial off-target effects BCG are proposed to be stronger amongst children who develop a scar. Within an international randomised trial (‘BCG reduce the impact coronavirus disease 2019 (COVID-19) in healthcare workers’; BRACE Trial), this nested prospective cohort study assessed and factors...

BCG vaccination significantly diminished proinflammatory responses in elderly individuals COVID-19 hot spots.

BacillusCalmette-Guerin (BCG) vaccine, a live attenuated strain of Mycobacterium bovis was developed in 1908 and it was first used in 1921. Its safety profile is widely accepted globally, with just a few side effects including cutaneous inflammatory papules and granulomas which are common within the first few weeks after vaccination. A few reports of delayed BCG granulomas many years following ...