BACKGROUND Benzimidazoles and triazoles are useful structures for research and development of new pharmaceutical molecules and have received much attention in the last decade because of their highly potent medicinal activities. FINDINGS A simple and efficient synthesis of triazole was carried out by treatment of 2-(4-azidophenyl)-1H-benzo[d]imidazole (6) with different types of terminal alkyn...

Antioxidant and radical scavenging properties of a series of 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole derivatives were examined. Free radical scavenging properties of compounds 11-30 and 33 were evaluated for the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion radical. In addition the inhibitory effects on the NADPH-dependent lip...

A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) ...

Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, an...

The aim of this review is to provide the systematic information synthetic scheme and biological activity synthesized benzimidazole derivatives. Benzimidazole widely used lead molecule for synthesis various types pharmacologically active moiety. It heterocyclic aromatic fused colorless solid having molecular mass 118.053 g/mol. basic in nature can be served as ligand coordination chemistry. bioa...

A one-pot multicomponent reaction of aryl aldehydes, 2-amino benzimidazole and ethyl 2-mercaptoacetate is described as an efficient and environmentally method for the synthesis of  some  novel  ethyl  2-((1H-benzo[d]imidazol-2-ylamino)(Aryl)methylthio)  acetates  in  the presence of nano-Copper Y Zeolite (NCZ) as a catalyst in ethanol at room temperature. After optimizing of r...

PdCl2, ZnCl2 and CuCl2 complexes of three benzimidazole derivatives two Schiff bases having the ferrocene group were synthesized characterized. It was unexpectedly noticed that Pd(II) Zn(II) exhibit paramagnetic characters corresponding to about one electron caused by moiety. For same reason, magnetic moment value Cu(II) also higher than anticipated values. Besides, antimicrobial activity inves...

3-Alkyl-thiazolo[3,2-a]benzimidazole derivatives are obtained in high yields via the corresponding 4-alkyl-N-3-(2-aminophenyl)-thiazoline-2-thiones which are easily prepared from 1,2-diaminobenzene, CS(2) and halogenoketones. This new route compares advantageously with the classical mercaptobenzimidazole routes in term of simplicity,isolated yields and availability of the starting materials.

a library of benzimidazole derivatives have been prepared through the reaction of o-phenylenediamine and aldehydes in the presence of catalytic amount of silica supported sodium hydrogen sulphate (NaHSO4-SiO2) under refluxing in ethanol solvent to obtained excellent yields. This method is simple, convenient, environmental friendly, reusable, efficient and practical.