The title compound, C(17)H(16)N(2)O(3)S, crystallizes in the thio-amide form with an intra-molecular N-H⋯O hydrogen bond across the thio-urea system. Mol-ecules are connected in chains parallel to [10] by hydrogen bonds from the second thio-urea N-H group to the benzoate C=O function.

The aim of the following research was to formulate benzyl benzoate in emulgel form and to evaluate the release of the medicament from it. Emulgel containing 25% w/w of benzyl benzoate was prepared by addition of a gelling agent; Carbopol 934 to an emulsion using Span 80 as emulsifying agent. The release of benzyl benzoate was determined by Franz diffusion cell using cellulose acetate membrane f...

Abstract Enzyme-catalyzed iterative ? -1,4-glycosylation of -glycosides is promising for bottom-up polymerization reducing-end-modified cello-oligosaccharide chains. Self-assembly the chains from solution yields crystalline nanocellulose materials with properties that are tunable by glycoside group used. Cellulose a reducing-end thiol interest to install controllable pattern site-selective modi...

Previous communications from this laboratory have presented evidence that the unsymmetrical thio ether, ZZ-S-(@-amino-~-carboxyethyl)homocysteine (cystathionine),’ may serve in lieu of cystine for the growth of rats (2) and that an enzyme is present in the liver capable of cleaving the thio ether to yield cysteine (3). Brand, in his original suggestion (4) regarding this thio ether as an interm...

We highlight fast Li-ion diffusion in hypothetical tetragonal ${\mathrm{Li}}_{10}{\mathrm{GeP}}_{2}{\mathrm{O}}_{12}$ (LGPO), as a counterpart to the well-known phases of orthorhombic (LISICON) LGPO, thio-LISICON, and ${\mathrm{Li}}_{10}{\mathrm{GeP}}_{2}{\mathrm{S}}_{12}$ (LGPS). use extended Car-Parrinello molecular dynamics canonical isobaric-isothermal ensembles, finding first that LGPO is ...

Highly potent and selective CYP2C19 inhibitors are not currently available. In the present study, N-3-benzyl derivatives of nirvanol and phenobarbital were synthesized, their respective (+)- and (-)-enantiomers resolved chromatographically, and inhibitor potencies determined for these compounds toward CYP2C19 and other human liver cytochromes P450 (P450s). (-)-N-3-Benzyl-phenobarbital and (+)-N...

In the title co-crystal, C5H3ClO2S·C13H9N, the components inter-act with each other via an O-H⋯N hydrogen bond. Acridine-acridine stacking, thio-phene-thio-phene stacking and acridine-thio-phene C-H⋯π inter-actions also occur in the crystal.

Bacteriophage-T4 and human type I DNA ligases were found capable of self-adenylating upon exposure to both riboand deoxyribo-[a-35S]thio-ATP. However, the joining reaction does not take place in the presence of the deoxyribotriphosphates. Enzyme adenylation is reversed in all cases by an excess of PP1, but the rate of reversion is lower with thio derivatives. Therefore thio derivatives can be u...

      In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...

In the title compound, C16H17NO3S, a thio-phene derivative with amino phenyl, acetyl, methyl and ethyl carboxyl susbtituents attached to a central thio-phene ring, the phenyl and thio-phene rings form a dihedral angle of 36.92 (9) Å. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯O hydrogen bond, which forms an S(6) ring motif.