We present a sensitive tracer method, suitable for in vivo human research, that uses beta-[(14)C]carotene coupled with accelerator mass spectrometry (AMS) detection. Using this approach, the concentration-time course of a physiological (306 microgram 200 nCi) oral dose of beta-[(14)C]carotene was determined for 209 days in plasma. Analytes included beta-[(14)C]carotene, [(14)C]retinyl esters, [...

background: skin cancer can be treated by various methods. electron radiotherapy has been a useful therapeutic modality in the treatment of skin cancers in areas which are difficult to cure by other methods. depth dose distribution of 166ho using varskin2 code is presented in this work. material and methods: depth dose distribution of 166ho was calculated, using varskin2 code by adding of 166ho...

Introduction Radiotherapy is regarded as the first treatment of choice for nasopharyngeal carcinoma. Despite the advantages of radiotherapy, patients may suffer from a wide range of side-effects due to the presence of many sensitive normal tissues in these regions. If the absorbed dose exceeds the tolerance level in parotid glands and the spinal cord, myelopathy, Lhermitte's sign and xerostomia...

UNLABELLED Absorbed dose profiles within tumor spheroids simulating avascular micrometastases have been calculated for a variety of liposome- and antibody-radionuclide combinations to assess the anticipated therapeutic efficacy based on the intratumoral distribution of the carrier systems within the spheroid model. METHODS Experiments studying the targeting and diffusion capability of the mos...

The calculation of absorbed dose from internally incorporated radionuclides is based on the so-called specific absorbed fractions (SAFs) which represent the fraction of energy emitted in a given source region that is absorbed per unit mass in a specific target organ. Until recently, photon SAFs were calculated using MIRD-type mathematical phantoms. For electrons, the energy released was assumed...

Hemoglobinopathy refers to a disease involving qualitative or quantitative defect of the structure synthesis haemoglobin molecules. The HaemoglobinS- beta thalassemia occurs in heterozygotes individual with beta-thalassemia and HaemoglobinS gene. A 29-year-old man came severe anemia, thrombocytopenia, history repeated blood transfusions. Physical examination showed pale conjunctiva, pansystolic...