Radioactive waste generated in decommissioning activities need be classified according to their radioactive content. The radiological information required by national authorities includes diverse alpha and beta emitters, which can only be determined after a radiochemical separation process. This paper presents the work on the development of radiochemical methods for the simultaneous separation ...

Purpose: Radionuclide therapy directed against tumors that express somatostatin receptors (SSTRs) has proven effective for the treatment of advanced, low- to intermediate-grade neuroendocrine tumors in the clinic. In clinical usage, somatostatin peptide-based analogs, labeled with therapeutic radionuclides, provide an overall response rate of about 30%, despite the high cumulative activity inje...

The development of radionuclide therapies during the past few decades provides a growing body of data on radiobiologic effects, including normal tissue toxicities and antitumor efficacy. Information on normal tissue toxicity from radionuclides is more limited than that from external beam radiation and appears to be more variable. Much of the increased variability is attributed to heterogeneous ...

Antibodies conjugated to radionuclides emitting low-energy electrons, which include Auger electrons and some conversion electrons, were recently shown to efficiently kill cells bearing a high density of the antigen recognized. The primary purpose of this study was to determine if such killing could be obtained with anti-HER-2 antibodies conjugated to (111)In, using the chelator benzyl-diethylen...

The emitted current as a function of applied voltage has been investigated for linear electrospray emitter arrays of different emitter separation distances. The emitter arrays were fabricated out of porous tungsten using conventional micro fabrication techniques adapted for use on porous substrates. Experimental results are provided for samples of each emitter density and show that the emitter ...

bebig ruthenium-106 ophthalmic plaques have been used for treatment of uveal melanoma, retinoblastoma, melanoma of the iris and other special applications for many years. the plaques consist of a thin film of 106ru, a beta emitter, encapsulated in pure silver. the present work proposes a new mathematical eye model for ophthalmic brachytherapy dosimetry. this new model includes detailed descript...

PURPOSE Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. ...

PET (positron emission tomography) is a powerful imaging technique that can provide quantitative information on the distribution of positron emitter labeled radiopharmaceuticals (PET radiopharmaceuticals) in the body. Positrons (ß+) are positively charged beta particles. They are emitted when the atom is proton rich. A positron has only a transient existence. After losing all of its kinetic ene...