To help elucidate the role of secondary structure packing preferences in protein folding, here we present an analysis of the packing geometry observed between alpha-helices and between alpha-helices and beta-sheets in 1316 diverse, nonredundant protein structures. Finite-length vectors were fit to the alpha-carbon atoms in each of the helices and strands, and the packing angle between the vecto...

AIM The present study aims to explore the effects of vitamin E and omega-3 on endothelial function indicators among adolescents with metabolic syndrome. METHOD In a randomized, double blind, and placebo-controlled trial, 90 young individuals, aged 10 to 18 years, with metabolic syndrome were randomly assigned to receive either vitamin E tablets (400 IU/day) or omega-3 tablets (2.4 gr/day) or ...

A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain Gliocladium sp. FTD-0668. Argifin was purified from the cultured mycelium by the combination of cation exchange, anion exchange, adsorption, and gel filtration chromatographic methods. The structure of argifin was elucidated as cyclo(N(omega)-(N-methylcarbamoyl)-L-arginyl-N-methyl-L-phenylalan yl-b...

We study the zero Dirichlet problem for equation $-\Delta_p u -\Delta_q = \alpha |u|^{p-2}u+\beta |u|^{q-2}u$ in a bounded domain $\Omega \subset \mathbb{R}^N$, with $1<q<p$. investigate relation between two critical curves on $(\alpha,\beta)$-plane corresponding to threshold of existence special classes positive solutions. In particular, certain neighbourhoods point $(\alpha,\beta) \left(\|\na...

Background: This study was conducted to determine the effects of n-3 PUFAs supplementation on plasma homocysteine (Hcy) level, lipid profile and insulin resistance in patients with type 2 diabetes (T2D). Methods: This study is a double-blind controlled trial involving 70 patients with T2D selected from Yazd Diabetes Research Center in 2013. Patients were randomly assigned to receive either 2 g/...

A library of 30 beta-lactams has been prepared from (3R,4R)-3-[(R)-1'-(tbutyldimethylsilyloxy)-ethyl]-4-acetoxy-2-azetidinone, and the corresponding deacetoxy derivative, by sequential N- and O-functionalizations with various omega-alkenoyl and omega-arylalkanoyl chains. All compounds were selective inhibitors of hFAAH versus hMGL, and IC(50) values in the nanomolar range (5-14 nM) were recorde...

Rhodobacter capsulatus NtrC is an enhancer-binding protein that activates transcription of the R. capsulatus sigma 70 RNA polymerase, but does not activate the Escherichia coli sigma 70-RNA polymerase at the nifA1 promoter. We utilized R. capsulatus:E. coli hybrid RNA polymerases assembled in vitro to investigate the subunits required for protein-protein interaction with RcNtrC at the nifA1mut1...

Abstract In this paper, we will focus on following nonlocal quasilinear elliptic system with singular nonlinearities: $$\begin{aligned} (S) \left\{ \begin{array}{ll} (-\Delta )_{p}^{s_1} u =\dfrac{1}{v^{\alpha _1}}+v^{\beta _1}&amp;{} \text { in }\Omega , \\ )_{q}^{s_2} =\dfrac{1}{u^{\alpha _2}}+u^{\beta _2}&amp;{} u,v=0 &amp;{} } ({I\!\!R}^N\setminus \Omega ) u,v&gt;0 \end{array} \right. \end{...

Let $$\Omega \subset {{\mathbb {R}}}^3$$ be an open set. We study the spectral properties of free Dirac operator $$ \mathcal {H} :=- i \alpha \cdot \nabla + m\beta coupled with singular potential $$V_\kappa =(\epsilon I_4 +\mu \beta \eta (\alpha N))\delta _{\partial \Omega }$$ , where $$\kappa ,\mu ,\eta )\in . The set can either a $$\mathcal {C}^2$$ -bounded domain or locally deformed half-spa...

The electronic structure and spectroscopic properties (R(e), omega(e), omega(e)x(e), beta(e), and T(e)) of the ground state and the 22 lowest excited states of chlorine molecule were studied within a four-component relativistic framework using the MOLFDIR program package. The potential energy curves of all possible 23 covalent states were calculated using relativistic complete open shell config...