نتایج جستجو برای: betulinic acid
تعداد نتایج: 747458 فیلتر نتایج به سال:
A new small-molecule inhibitor class that targets virion maturation was identified from a human immunodeficiency virus type 1 (HIV-1) antiviral screen. PF-46396, a representative molecule, exhibits antiviral activity against HIV-1 laboratory strains and clinical isolates in T-cell lines and peripheral blood mononuclear cells (PBMCs). PF-46396 specifically inhibits the processing of capsid (CA)/...
Schleichera oleosa (Lour.) Oken. is a medicinal plant of Bangladesh with enormous traditional applications in folk medicine. The current study was designed to isolate the secondary metabolites by successive chromatographic separation n-hexane and dichloromethane soluble fractions methanol extract leaves S. oleosa. A total four compounds were separated identified as 5,7-dihydroxy-4'-methoxyflavo...
Acetylated betulinic acid ( BA ) was converted into mono-substituted benzylamides 2 – 14 . Screening in SRB assays showed them as cytotoxic for a variety of different human tumor cell lines. While parent not within the limits assay (cut-off 30 μM), target amides were cytotoxic. Their bioactivity well their cell/non-tumor selectivity depended on substitution pattern aromatic ring. The most acti...
Pentacyclic triterpenoic acids, betulinic acid, platanic oleanolic acid and ursolic were acetylated subsequently converted into mono-, bis- tris(hydroxyl)ethyl amides. While parent compounds are of none or minor cytotoxicity, these amides showed EC50 values even in low μM concentration for a variety different human tumor cell lines. Especially bis(hydroxyethyl)amide 12 derived from held an = 7....
People have used carnivorous plants of the genus Sarracenia in folk medicine for centuries due to biochemical composition plants, which are rich numerous bioactive compounds with anti-inflammatory, antioxidant, antiviral and antibacterial properties. The subject this study was genetic transformation purpurea L. Agrobacterium rhizogenes strains 15834, 9402 A4 using two different methods: bacteri...
Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Several anticancer agents including taxol, vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, and etoposide derived from epipodophyllotoxin are in clinical use all over the world. A number of promising agents such as f...
In continuation of our studies on the phytochemical investigation of medicinal plants available in the foothills of Darjeeling and Teri, we report herein the isolation of two triterpenoids betulinic acid and lupeol from the leaf extract of Psidium guajava and their potential antimicrobial and phytotoxic activities. All the structures of the isolated compounds were confirmed by spectral (IR, NMR...
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