Ogston & Phelps (1961) found that hyaluronic acid markedly affects the partition of diffusible macromolecules between solutions of the polysaccharide and buffer. The authors explain the phenomenon as a steric exclusion of macromolecular solutes from solutions containing randomly coiled hyaluronic acid chains. From these results one can expect that hyaluronic acid and similar substances would ex...

BACKGROUND AND PURPOSE Dextranomer/hyaluronic acid copolymer implants are used in treating velopharyngeal insufficiency. These posterior nasopharyngeal implants can be mistaken for pathologic conditions such as retropharyngeal abscess on imaging. We studied the imaging appearance of dextranomer/hyaluronic acid copolymer implants in patients treated for velopharyngeal insufficiency. MATERIALS ...

Some of the anticarcinogenic effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) are attributable to the induction of detoxifying enzymes in the liver and peripheral tissues. This study was designed to determine if the tissue specificity of enzyme induction could be manipulated by structural modification of BHA. The induction of glutathione S-transferases and quinone reductase (EC 1.6.99.2) by th...

An affinity immunological procedure for hyaluronic acid detection on tissue sections is described. This new, sensitive, and specific technique is based on the high affinity of hyaluronectin for hyaluronic acid, utilizing anti-hyaluronectin-hyaluronectin immune complexes. Elimination of binding when the reagent was supplemented with hyaluronic acid or when Streptomyces hyaluronidase-digested tis...

A high degree of viscosity is the most striking physical attribute of normal synovial fluid. Although its direct relationship to the lubrication of joints remains uncertain, this viscosity still reflects physiologically important properties of hyaluronic acid. The anomalous viscosity which is a particular feature of hyaluronic acid in synovial fluid depends not only on the concentration and pol...

Rheumatoid arthritis *is considered a disease which involves the connective tissue and supporting structures of the body with its primary nidus in the interfibrillar ground substance of these structures (1). The ground substances are thought to be composed of mucopolysaccharide-protein complexes. The nature of two of the polysaccharides is known-chondroitin sulfuric acid and hyaluronic acid. Th...

Background: Abdominal adhesions are considered as an important problem in abdominal surgery. In this study we compared the effectiveness of atorvastatin, hyaluronic acid and interceed (oxidized cellulose) in prevention of postoperative intestinal adhesions. Material and Methods: A total of 40 Wistar-albino rats were randomly divided into 5 groups: Group 1 (Sham); Group 2 (Control ...

Background: One of the most important issues for patients with osteoarthritis is reducing pain and returning them to normal life. In addition to losing weight and improving daily activities, pain management treatments may be needed. One of these treatments is the injection of hyaluronic acid gel into the knee joint, which has been studied in this study. Methods: In this stud...

The classic Lossen rearrangement is a well-known reaction describing the transformation of an O-activated hydroxamic acid into the corresponding isocyanate. In this study, we found that chlorinated benzoquinones (CnBQ) serve as a new class of agents for the activation of benzohydroxamic acid (BHA), leading to Lossen rearrangement. Compared to the classic one, this new kind of CnBQ-activated Los...

The antioxidant effects of clove oil (CO) and clove oleoresin (COR) in two species of meat i.e. chicken and chevon during refrigerated storage (4±1°C) were investigated. The antioxidant potential (AOP) and radical scavenging activities were compared with natural (α-Tocopherol and L-ascorbic acid) and synthetic antioxidants (BHA and TBHQ). CO & TBHQ, BHA and COR and L-ascorbic acid and α-Tocophe...