Phototherapy is a safe, effective method for decreasing or preventing the rise of serum unconjugated bilirubin levels and reduces need exchange transfusion in neonates. The aim phototherapy to decrease level order prevent acute encephalopathy, hearing loss kernicterus. Mainly 5 types jaundice- pathological jaundice, physiological breast milk breastfeeding jaundice prematurity. works by 3 proces...

The efficacy of methylprednisolone (1 g daily or three days), which is effective in reversing transplant rejection, was assessed in a randomised controlled trial of 55 patients with severe acute alcoholic hepatitis, 34 of whom had encephalopathy. The clinical progress, frequency of bleeding and sepsis, and cause of death were similar in the treatment (27 patients) and control groups (28 patient...

Submit Manuscript | http://medcraveonline.com Abbreviations: CA: Carnitine; T-CA: Total Carnitine; F-CA: FreeCarnitine; Ac-CA: Acyl-Carnitine; L-CA: Levo-Carnitine; LC: Liver Cirrhosis; BTR: Branched-chain amino acids to Tyrosine Ratio; OHE: Overt Hepatic Encephalopathy; MHE: Minimal Hepatic Encephalopathy; eGFR: estimated Glomerular Filtration Rate; CKD: Chronic Kidney Disease; FFA: Free Fatty...

Introduction: Hepatic encephalopathy (HE) is a frequent complication and one of the most debilitating manifestations liver cirrhosis, which negatively impacts patient survival. This study aims to identify factors influencing treatment response in patients with cirrhosis HE.
 Method: was prospective observational conducted from July 2019 June 2020 tertiary referral center Nepal. The ethical...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency may cause severe hyperbilirubinemia with bilirubin encephalopathy unless intervention is initiated. The aim of this study was to assess the efficacy of clofibrate in full term G6PD deficient neonates with jaundice. A randomized clinical trial study was performed in two groups of full-term G6PD deficient jaundiced neonates (clofibrate treated g...

Neonatal jaundice is a common physiological problem affecting over half of all full term and most preterm infants. Thus, newborn infants must be monitored for signs of hyperbilirubinemia to prevent acute bilirubin encephalopathy or kernicterus. Evidence exists supporting the benefits of baby massage as a form of mild hand to skin contact, to increase neonatal physical and mental development. In...

Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-glucuronosyltransferase 1A1 (UGT1A1) and the inability to metabolize bilirubin. Although there is a good understanding of the early events after birth that lead to the rapid increase in serum bilirubin, the events that control delayed expression of UGT...

Cytotoxicity by unconjugated bilirubin involves disturbances of membrane structure, excitotoxicity and cell death. These events were reported to trigger elevated free radicals production and impairment of calcium homeostasis, and to result in loss of cell membrane integrity. Therefore, this study was designed to investigate whether interaction of clinically relevant concentrations of free uncon...

Severe hyperbilirubinemia can induce devastating and permanent neurodevelopmental handicaps in infants. The occurrence of hyperbilirubinemia is higher in late preterm than in term infants, ranging from 8 to 40% of the formers according to different definitions of hyperbilirubinemia. The mechanisms by which this occurs is not completely understood, however an increased bilirubin load on hepatocy...