Some drugs have low bioavailability due to their poor aqueous solubility and/or slow dissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that is structurally unrelated to the currently available antiepileptics. It has poor aqueous solubility and its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) is commonly utilized as a hydroph...

mechanical alloying of binary and ternary elemental powder mixtures with the nominal compositions of mg2ni and mg(2-x)mnxni (x= 0, 0.05, 0.10 and 0.15 at. %) were carried out in a planetary ball mill for various milling times of 5, 10, 15, 20, 30 and 60 h. x-ray diffraction and field emission scanning and transmission electron microscopy were used for the characterization of the milled products...

The question of whether a binary mixture of amino acids is detected by fish as a unique odor or whether the qualities of the individual components are retained within the mixture was investigated in channel (Ictalurus punctatus) and brown bullhead (Ameiurus nebulosus) catfish, species that are highly similar in their olfactory receptor and behavioral responses to amino acid odorants. Catfish re...

We have applied density functional methods to predict the nucleation rates of bubbles in superheated, stretched, or supersaturated binary fluid mixtures. Our model uses Lennard-Jones mixtures, with mixing rules chosen to allow either ideal or nonideal solution behavior. Deviations from the predictions of classical nucleation theory are in general quite large, with the locus of observable bubble...

The phenomenological model of Khossravi and Connors (1992) has been adopted to calculate the electrophoretic mobility of drugs at different concentrations of solvents in a binary mixture. The accuracy and predictability of the model have been evaluated employing 14 experimental data sets by using average percentage mean deviation (APMD). The obtained APMD for correlative and predictive studies ...

In this study, the pressure drop for the binary mixtures of particles differing in size and density in a pseudo-2D spouted bed was experimentally studied. A binary mixture of solid particles including sand, Gypsum, and polyurethane was used in the experimental setup. Effects of static bed height, cone angle, particles diameter, and a particles weight fraction on the bed pressure drop were e...

Abstract A pulsation heat pipe is an efficient used in many engineering applications. This study aims to test the effect of working fluids on thermal performance pipe. Seven turned pipes were designed and manufactured from a copper with 3.5 mm inner diameter. The lengths evaporation part, adiabatic passage, condenser part 300 , 210 respectively. In this study, three different as fluid: distille...

In this paper the steady state performance of a variable conductance heat pipe, which its working fluid consists of two components (R11+ R113) is modeled. The role of the liquid film momentum and axial normal stresses are considered by use of the mean property of mixture and the governing equations are solved by conventional numerical methods. The results of the present model have been compared...