نتایج جستجو برای: binding cassette transporter

تعداد نتایج: 464028  

Journal: :The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique 2009
R D Sawant

A case report of a ciprofloxacin and simvastatin interaction is presented. The addition of ciprofloxacin to chronic simvastatin therapy led to the development of rhabdomyolysis. As ciprofloxacin is a weak inhibitor of CYP3A4, it is very likely that other mechanisms involving the ATP-binding cassette drug efflux transporter family played a role in this drug interaction.

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2003
Robert J Aiello Dominique Brees Omar L Francone

Studies with ATP-binding cassette transporter (ABCA1)-deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1-deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on ...

Journal: :Cell 2017
Jyh-Yeuan Lee Daniel M. Rosenbaum

The subfamily C ATP-binding cassette (ABCC) transporters mediate multidrug resistance and ion conductance regulation. Recent atomic or near-atomic resolution structures of three physiologically significant ABCC transporters (MRP1, SUR1, and CFTR), determined by using single-particle cryo-electron microscopy (cryo-EM), reveal structural details that help explain the wide functional diversity of ...

2003
Robert J. Aiello Dominique Brees Omar L. Francone

Studies with ATP-binding cassette transporter (ABCA1)–deficient mice have been critical in demonstrating the relation between ABCA1 expression, cellular lipid efflux, and HDL metabolism. The phenotype of the ABCA1deficient mouse parallels the phenotype observed in human Tangier disease, including substantial reductions in both apolipoprotein B and apolipoprotein AI with confounding affects on a...

Journal: :Applied and environmental microbiology 2001
G Cabrera A Xiong M Uebel V K Singh R K Jayaswal

To investigate iron uptake, a chromosomal locus containing three consecutive open reading frames, designated fhuC, fhuB, and fhuD, was identified in Staphylococcus aureus. Whereas the fhuC gene encodes an ATP-binding protein, fhuB and fhuD code for ferrichrome permeases and thus resemble an ATP-binding cassette transporter. A fhuB knockout mutant showed impaired uptake of iron bound to the side...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Ailing Ji Joanne M Wroblewski Nancy R Webb Deneys R van der Westhuyzen

OBJECTIVE Phospholipid transfer protein (PLTP), which binds phospholipids and facilitates their transfer between lipoproteins in plasma, plays a key role in lipoprotein remodeling, but its influence on nascent high-density lipoprotein (HDL) formation is not known. The effect of PLTP overexpression on apolipoprotein A-I (apoA-I) lipidation by primary mouse hepatocytes was investigated. APPROAC...

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