The human ACE2 enzyme serves as a critical first recognition point of coronaviruses, including SARS-CoV-2. In particular, the extracellular domain interacts directly with S1 tailspike protein SARS-CoV-2 virion through broad protein–protein interface. Although this interaction has been characterized by X-ray crystallography, these structures do not reveal significant differences in structure upo...

COVID-19 is caused by the novel enveloped beta-coronavirus with a genomic RNA closely related to severe acute respiratory syndrome-corona virus (SARS-CoV) and named coronavirus 2 (SARS-CoV-2). In this study, six synthetic drugs were specifically docked against RBD. Most of compounds observed fit nicely specific noncovalent interactions. Oseltamivir was found be most strongly interacting RBD, ex...

The mechanism of plasmid mediated silver (Ag) resistance was investigated in Acinetobacter baumanniiBL54. The intracellular accumulation of Ag in both original strain BL54 and Escherichia coli K12transconjugant containing plasmid pUPI276 began immediately and reached a maximum within 60 minutes.This initial accumulation was followed by net loss of Ag which reached a maximum wi...

Horseradish peroxidase (HRP), has gained significant interests in biotechnology, especially in biosensor field and diagnostic test kits. Hence, its solvent-exposed lysine residues 174, 232, and 241 have been frequently modified with the aim of improving its stability and catalytic efficiency. In this computational study, we investigated the effects of Lys-to-Glu substitutions on HRP structure t...

abstract introduction: there is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. insulin receptors hybridize with insulin like growth factor receptor (igf-i) to transduce the signals in different areas of the brain. in this article we aimed at investigating whether the expression of igf-i receptor and igf-i binding proteins (igfbp1) is changed...

There are questions concerning the functions of artemin, an abundant stress protein found in Artemiaduring embryo development. It has been reported that artemin binds RNA at high temperatures in vitro, suggesting an RNA protective role. In this study, we investigated the possibility of the presence of RNA-bindingsites and their structural properties in artemin, using docking energy ...