Synthetic biomaterials mimicking bone morphology have expanded at a tremendous rate. Among all, one stands out: bioactive glass. Bioactive glasses opened the door to a new genre of research into materials able to promote the regeneration of functioning bone tissue. However, despite their ability to promote cell attachment, proliferation and differentiation, these materials are mainly used as gr...

Bioactive glass has high potential for bone regeneration due to its ability to bond to bone and stimulate osteogenesis whilst dissolving in the body. Although three-dimensional (3-D) bioactive glass scaffolds with favorable pore networks can be made from the sol-gel process, compositional and structural evolutions in their porous structures during degradation in vivo, or in vitro, have not been...

Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bones is limited due to their low fracture toughness and fairly fast degradation response in vivo. In this paper, we describe our investigation of freeform extrusion fabrication of silicate based 13-93 bioactive glass scaffolds reinforced with titanium fiber...

OBJECTIVE To explore the application value of injectable bioactive glass in the restoration of the oral bone defect. PATIENTS AND METHODS This study included 58 consecutive patients with oral bone defect > 1 mm, these patients were randomly assigned to a control group (n=26, Hydroxyapatite bioceramics) and an observation group (n=32, Injectable bioactive glass). The purpose of this study was ...

The guided bone regeneration (GBR) procedure has been used successfully when there is insufficient bone volume for implant placement 1-3) . Bone graft materials are used in conjunction with barrier membranes to improve the outcomes of GBR procedures: they stabilize the blood clot, prevent membrane shrinkage and maintain the space available for new bone formation beneath the membrane 4-6) . Auto...

Bioactive glass is used as both a bone filler and as a coating on implants, and has been advocated as a potential osteogenic scaffold for tissue engineering. Rat-derived mesenchymal stem cells (MSCs) show elevated levels of alkaline phosphatase activity when grown on 45S5 bioactive glass as compared to standard tissue culture plastic. Similarly, exposure to the dissolution products of 45S5 elev...

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass) particles. Stable and homogeneous Bioglass coatings on the surface of PDLLA foams as well as infiltration of Bioglass particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with p...