Elżbieta Skrzydlewska Department of Analytical Chemistry, Medical University of Białystok15-230 Białystok 8, P. O. Box 14, Poland The goal of this Special Issue on Bioanalytical Methods in Toxicology is to recapitulate the latest achievements concerning the theory and practice of modern chromatography and related techniques. The interest of such significant and current issues has not been accid...

OBJECTIVE Volume overload from an incorrect assessment of dry weight leads to cardiovascular diseases in chronic hemodialysis patients. Dry weight assessment in pediatric is difficult for a number of reasons including growth. Blood volume monitoring (BVM) has been proposed as an accurate method of estimating dry weight in adult. However, there is very scant data regarding B VM assessment in ped...

Polarization curves are of paramount importance for the detection of toxic components in microbial fuel cell (MFC) based biosensors. In this study, polarization curves were made under non-toxic conditions and under toxic conditions after the addition of various concentrations of nickel, bentazon, sodiumdodecyl sulfate and potassium ferricyanide. The experimental polarization curves show that to...

The unity of opposites in the title is essentially that between logic and geometry, and there are compelling reasons for maintaining that geometry is the leading aspect. At the same lime, in the present joint work with Myles Tierney there are important influences in the other direction: a Grothendieck " topology " appears most naturally as a modal operator, of the nature " it is locally the cas...

In this text we will formalise a novel solution, the Bayesian Volumetric Map (BVM), as a framework for a metric, short-term, egocentric spatial memory for multimodal perception of 3D structure and motion. This solution will enable the implementation of top-down mechanisms of attention guidance of perception towards areas of high entropy/uncertainty, so as to promote active exploration of the en...

An accurate and precise micellar LC method coupled with UV and fluorimetric detectors was developed and validated for the simultaneous analysis of furosemide, metoprolol and verapamil in human plasma. The total analysis time was 25 min (12 min for sample preparation and 13 min for drug separation). All drugs possessed linear behavior (r > 0.999 for calibration curves) in their therapeutic conce...

Quantitative targeted proteomics based approaches deploy state-of-the-art Liquid chromatography tandem mass spectrometry LC-MS technologies and are evolving as a complementary technique to standard ligand-binding based assays. Advancements in MS technology, which have augmented the specificity, selectivity and sensitivity limits of detection and freedom from antibody generation, have made it am...

Biologics such as monoclonal antibodies and recombinant proteins represent a significant portion of the pharmaceutical market. With many of the first generation biologics' patents expiring, an increasing number of biosimilars will be submitted for approval in the near future. The successful development of a biosimilar requires the demonstration of biosimilarity in terms of efficacy, safety and ...