Haloarchaea are adapted to high-salt environments and accumulate equally high salt concentrations in the cytoplasm. The genomes of representatives of six haloarchaeal genera have been fully or partially sequenced, allowing the analysis of haloarchaeal properties in silico. Transcriptome and proteome analyses have been established for Halobacterium salinarum and Haloferax volcanii. Genetic syste...

The generation of distinct neuronal cell types in appropriate numbers and at precise positions underlies the assembly of neural circuits that encode animal behavior. Despite the complexity of the vertebrate central nervous system, advances have been made in defining the principles that control the diversification and patterning of its component cells. A combination of molecular genetic, biochem...

INTRODUCTION .......................................... 403 COLOR VISION .......................................... 405 RED AND GREEN PIGMENTS ................................. 406 Psychophysics of Red~Green Color Blindness ....................... 406 Molecular Genetics of RedIGreen Color Blindness .................... 407 Variation in Normal Color Vision .............................. 409 Blue...

Department of Biochemistry and Department of Human Genetics, Cardiovascular Research Laboratories, Cardiology Division, Faculty of Medicine, McGill University Health Centre/Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada. Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Department of Medicine, Helsinki University Central Hospital, HUS...

Alzheimer disease represents an insidious impairment of intellect and emotional well-being. However, recent advances in biochemical pathology and human genetics offer promise that effective therapeutic agents may soon be developed.

a series of new concepts about the nlature of inherited variations in huinaii biochemistry which are now part of our thinking in I)iochemical genetics. It is interesting that these concepts, formulated by a practising physician, were largely neglected until in a new climate of thinking they were in part rediscovered by scientists working with totally different material. Only in the last decade ...

Biochemistry and genetics are both required to elucidate the function of macromolecules. There is no question that metallothioneins (MTs) have unique biochemical properties, but genetic experiments have not substantiated the importance of MTs under physiological conditions. Even after thousands of studies describing the structure, biochemical characteristics, tissue distribution, induction, and...