Magnesium-Calcium (Mg-Ca) alloy has received considerable attention as an emerging biodegradable implant material in orthopedic fixation applications. The biodegradable Mg-Ca alloys avoid stress shielding and secondary surgery inherent with permanent metallic implant materials. They also provide sufficient mechanical strength in load carrying applications as opposed to biopolymers. However, the...

The use of osteofixation devices should be evidence-based if uncomplicated bone healing is to be achieved. Numerous studies describe and claim the advantages of biodegradable over titanium devices as a bone fixation method. Here, we systematically review the available literature to determine the clinical efficacy and safety of biodegradable devices compared with titanium devices in oral and max...

“Diagnosis is not the end, but the beginning of practice”, said the Nobel Laureate in medicine Martin H. Fischer. A main objective for engineers working in the biomedical field is to provide tools to medical doctors which help them in making accurate diagnose. In particular, getting access to in vivo physiological parameters in real-time is of great interest. The concept presented in this thesi...

OBJECTIVE To compare the efficacy and safety of biodegradable polymer drug eluting stents with those of bare metal stents and durable polymer drug eluting stents. DESIGN Mixed treatment comparison meta-analysis of 258,544 patient years of follow-up from randomized trials. DATA SOURCES AND STUDY SELECTION PubMed, Embase, and Central were searched for randomized trials comparing any of the Fo...

BACKGROUND Refractory benign esophageal strictures (RBESs) have been treated with the temporary placement of different self-expanding stents with conflicting results. We compared the clinical effectiveness of 3 types of stents: self-expanding plastic stents (SEPSs), biodegradable stents, and fully covered self-expanding metal stents (FCSEMSs), for the treatment of RBES. METHODS This study pro...

An array of highly sensitive pressure sensors entirely made of biodegradable materials is presented, designed as a single-use flexible patch for application in cardiovascular monitoring. The high sensitivity in combination with fast response time is unprecedented when compared to recent reports on biodegradable pressure sensors (sensitivity three orders of magnitude higher), as illustrated by p...

A mathematical model was developed to relate the degradation trend of bioresorbable polymers to different underlying hydrolysis mechanisms, including noncatalytic random scission, autocatalytic random scission, noncatalytic end scission or autocatalytic end scission. The effect of each mechanism on molecular weight degradation and potential mass loss was analysed. A simple scheme was developed ...

In this technology report, three test methods were developed to characterize the degradation of plastic in marine environment. The aim was to outline a test methodology to measure the physical and biological degradation in different habitats where plastic waste can deposit when littered in the sea. Previously, research has focused mainly on the conditions encountered by plastic items when float...

Sadr`aj: Market Overview; Structure and Properties; Brief Description of the Properties of Generic Polymeric Materials; Physical Properties – Characteristic Values – Test Methods and Procedures; Calculation for Structures under Mechanical Load – Examples of Geometrically Simple Structural Parts under Static Loads; Design and Material Consideration for Parts Subjected to Mechanical Loads; Design...

the delivery of therapeutic proteins has gained momentum with development of biotechnology. however, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (git) resulted in low absorption. the main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhgh) on the basis of parti...