Purpose:Discriminant markers for pancreatic cancer detection are needed. We sought to identify and validate methylated DNA markers for pancreatic cancer using next-generation sequencing unbiased by known targets. Experimental Design: At a referral center, we conducted four sequential case–control studies: discovery, technical validation, biologic validation, and clinical piloting. Candidatemark...

Recent advances in genomic technology have led to considerable improvement in our understanding of the molecular basis that underpins breast cancer biology. Through the use of comprehensive whole genome genomic profiling by next-generation sequencing, an unprecedented bulk of data on driver mutations, key genomic rearrangements, and mechanisms on tumor evolution has been generated. These develo...

summary: adult-onset still’s disease (aosd) is a rare systemic inflammatory disorder of unknown etiology. it is characterized by high grade fever, skin rash, arthritis, leukocytosis, increased esr, crp and liver enzyme levels and high levels of ferritin. the treatment of aosd includes nsaids, steroids, and disease-modifying antirheumatic drugs (dmards). recently biologic agents have been used f...

the nutrient elements uptake in many of soils, is a problem because of high ph and plenty of calcium ions in them. some of these elements are phosphorus and microelements. it is possible to increase absorption of these nutrient elements by addition of sulfur in soil and biological oxidation. the rate of this reaction is very slow and thiobacillus bacteria are the most important oxidators of sul...

A third of patients with epithelial ovarian cancer (OVCA) will not respond to standard treatment. The determination of a robust signature that predicts chemoresponse could lead to the identification of molecular markers for response as well as possible clinical implementation in the future to identify patients at risk of failing therapy. This pilot study was designed to identify biologic proces...

The National Children's Study is a proposed longitudinal cohort study to evaluate the relationships between children's health and the environment. Enrollment is estimated to begin in September 2005, and 100,000 children will be followed from preconception or early pregnancy until adulthood. Among multiple health outcomes, the study is proposing to investigate whether pre- and/or postnatal expos...