BACKGROUND Osteochondral autografts and allografts have been widely used in the treatment of isolated grade IV articular cartilage lesions of the knee. However, the authors are not aware of any study that has prospectively compared fresh osteochondral autografts to fresh allografts with regard to imaging, biomechanical testing, and histology. HYPOTHESIS The imaging, biomechanical properties, ...

Osteochondral grafting for cartilage lesions is an attractive surgical procedure; however, the clinical results have not always been successful. Surgical recommendations differ with respect to donor site and graft placement technique. No clear biomechanical analysis of these surgical options has been reported. We hypothesized that differences in graft placement, graft biomechanical properties, ...

Background: Autoregulation of blood flow is a marvelous phenomenon balanc- ing blood supply and tissue demand. Although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. The biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comp...

BACKGROUND All of previous biomechanical studies on meniscal repair have examined the meniscus itself without synovial membrane and capsule, although in the clinical setting, the meniscal repair is generally performed including capsule. Therefore, biomechanical properties of transcapsular meniscal repair are unclear. Thus, this study aimed to clarify the biomechanical properties of transcapsula...

The biomechanical properties of soft tissue derived from experimental measurements are critical for developing a reality-based model for minimally invasive surgical training and simulation. In our research, we focus on developing a biomechanical model of the liver under large tissue deformation. This paper presents the experimental apparatus, experimental data, and formulations to model the exp...

BACKGROUND The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal models. In contrast, there is limited study showing the effects of dietary gelatin hydrolysates from fish on BMD. The quantity and structure of peptides in the plasma after oral a...

Allograft safety is contingent on effective sterilization methods such as gamma irradiation. However, recent clinical studies have associated gamma irradiation with decreased graft strength and increased allograft failure rates, despite data that shows no deleterious effects to soft tissue biomechanics at gamma doses between 1.46 and 2.18 mRad. The objective of this study was to compare the bio...