Imaging through thick highly scattering media (sample thickness ≫ mean free path) can realize broad applications in biomedical and industrial imaging as well as remote sensing. Here we propose a computational "All Photons Imaging" (API) framework that utilizes time-resolved measurement for imaging through thick volumetric scattering by using both early arrived (non-scattered) and diffused photo...

Semiconductor quantum dots are tiny light-emitting nanocrystals (2-10 nm) that have captivated researchers in the biomedical field in the last decade. Compared to organic dyes and fluorescent proteins, quantum dots (QDs) have unique optical properties such as tunable emission spectra, improved brightness, superior photostability, and simultaneous excitation of multiple fluorescence colors. Sinc...

Quantum information science promises transformative impact over a range of key technologies in computing, communication, and sensing. A prominent example uses entangled photons to overcome the resolution-degrading effects of dispersion in the medical-imaging technology, optical coherence tomography. The quantum solution introduces new challenges: inherently low signal and artifacts, additional ...

s and Conference Proceedings X. Li, T. H. Ko, and J. G. Fujimoto, “Intraluminal fiber optic Doppler imaging catheter for structural andfunctional optical coherence tomography,” Photonics West, SPIE, San Jose, CA, January 19-25, 2002,paper 4619-22. T. H. Ko, I. Hartl, W. Drexler, R. K. Ghanta, and J. G. Fujimoto, “Ultrahigh resolution optical coherencetomography for quantitative topo...

In this paper, we examine the potential of a fully noncontact-standoff laser-ultrasound concept to generate and measure elastic waves in order to construct internal structure and matrix images within biological tissue. We use a pulsed optical laser (Q-switched) as an excitation source that converts optical energy to ultrasonic waves within a tissue complex via photoacoustic (PA) mechanisms. Las...

This symposium was held on June 1-2, 2009 at NIH. The meeting was organized by NEI and jointly supported by NEI and NIBIB as a part of the NEI 40th Anniversary Symposia Series. The meeting brought together many of the world’s leading experts in ocular imaging technology to discuss the current state of the art in optical coherence tomography (OCT), adaptive optics (AO), fluorescence imaging, and...

Diffuse optical imaging is a functional medical imaging modality which takes advantage of the relatively low attenuation of near-infrared light to probe the internal optical properties of tissue. The optical properties are affected by parameters related to physiology such as the concentrations of oxyand deoxyhemoglobin. Instrumentation that is used for optical imaging is generally able to measu...

Diffuse optical tomography is emerging as a viable new biomedical imaging modality. Using visible and near-infrared light this technique can probe the absorption and scattering properties of biological tissues. The main applications are currently in brain, breast, limb and joint imaging; however, optical tomographic imaging of small animals is attracting increasing attention. This interest is f...

Gold nanorods (NRs) have plasmon-resonant absorption and scattering in the near-infrared (NIR) region, making them attractive probes for in vitro and in vivo imaging. In the cellular environment, NRs can provide scattering contrast for darkfield microscopy, or emit a strong two-photon luminescence due to plasmon-enhanced two-photon absorption. NRs have also been employed in biomedical imaging m...

We have synthesized and characterized gold nanoparticles (spheres and rods) with optical extinction bands within the "optical imaging window." The intense plasmon resonant driven absorption and scattering peaks of these nanoparticles make them suitable as contrast agents for optical imaging techniques. Further, we have conjugated these gold nanoparticles to a mouse monoclonal antibody specific ...