In order to select a suitable combination of cancer cell lines as an appropriate source of antigens for dendritic cell-based immunotherapy of ovarian cancer, we analyzed the expression level of 21 tumor associated antigens (BIRC5, CA125, CEA, DDX43, EPCAM, FOLR1, Her-2/neu, MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A6, MAGE-A10, MAGE-A12, MUC-1, NY-ESO-1, PRAME, p53, TPBG, TRT, WT1) in 4 establi...

Chromosomal alterations are frequent events in lung carcinogenesis and usually display regions of focal amplification containing several overexpressed oncogenes. Although gains and losses of chromosomal loci have been reported copy number changes of the individual genes have not been analyzed in lung cancer. In this study 22 genes were analyzed by MLPA in tumors and matched normal tissue sample...

Subunit vaccines containing universal tumor associated antigens (TAAs) present an attractive treatment modality for cancer primarily due to their safety and potential to generate long-term immunological responses that can safeguard against recurrences. However, TAA-based subunit vaccines require potent adjuvants for therapeutic efficacy. Using a novel form of the 4-1BBL costimulatory molecule, ...

Immune-related genes are important factors in tumor progression. The main aim of this study was to identify the immune-related kidney papillary cell carcinoma (pRCC) patients. We downloaded RNAseq data and clinical information pRCC patients from TCGA database retrieved list Immport. From data, we mined out 2,468 differential expression (DEGs) 183 DEGs. Four hub DEGs ( NTS , BIRC5 ELN CHGA ) wer...

Tumor cells have a dysregulated cell cycle that may render their proliferation especially sensitive to the inhibition of cyclin-dependent kinases (CDKs), important regulators of cell cycle progression. We examined the effects of CDK1 inhibition in the context of different oncogenic signals. Cells transformed with MYC, but not cells transformed by a panel of other activated oncogenes, rapidly un...

Abstract— Previously we demonstrated the tumor-specific activity of several human native and chimeric promoters. Here have analyzed DNA sequences experimentally tested promoters for presence recognition matrices transcription factors de novo motif discovery. CiiiDER MEME Suite software tools were used this purpose. A number factor been identified, which are present more often in than housekeepi...