Verrucous epidermal nevi ― hamartomas of keratinocyte or appendages, located on the skin mucous membranes in form isolated birthmarks, less often have a linear localization. The pathogenesis verrucous has not been fully defined, probably development disease is associated with genetic mutations during embryogenesis and represent special mosaicism. are pathologies that require attention as potent...

BACKGROUND Pulsed dye laser (PDL) is a commonly utilized treatment for port wine stain birthmarks (PWS) in the United States; however, results are variable and few patients achieve complete removal. Photodynamic therapy (PDT) is commonly used in China, but treatment associated photosensitivity lasts several weeks and scarring may occur. We propose an alternative treatment option, combined PDT+P...

Background Port-wine stain (PWS) birthmarks currently are treated using a pulsed dye laser (PDL) combined with transient cooling of the epidermis. PDL treatment protocols utilize short pulses of light (585 or 595 nm wavelength) to heat selectively the microvasculature due to absorption by intravascular hemoglobin. Although most patients respond to PDL therapy, few experience complete removal of...

Port-wine stain is a type of common congenital superficial telangiectasia in the dermal layer mostly occurring on the forehead, face, and neck. The affected skin shows abnormal red or purple lesions, which darken and thicken. Nodular changes may develop with advancing age. If untreated, port-wine stains scarcely regress, which can have serious lifelong psychological impact on patients and affec...

DEAR EDITOR, GNA11 and GNAQ are highly homologous genes encoding different Ga subunits of heterotrimeric G-proteins. We recently described postzygotic activating mutations in GNA11 or GNAQ as causes of phakomatosis pigmentovascularis (PPV), and GNAQ mosaicism as a cause of extensive dermal melanocytosis (EDM). GNAQ mosaicism has previously been found to cause Sturge–Weber syndrome (SWS) and iso...

Heat transfer rate at the skin-air interface is of critical importance for the benefits of cryogen spray cooling in combination with laser therapy of shallow subsurface skin lesions, such as port -wine stain birthmarks. With some cryogen spray devices, a layer of liquid cryogen builds up on the skin surface during the spurt, which may impair heat transfer across the skin surface due to relative...

OBJECTIVE To determine the prevalence of neonatal dermatological findings and analyze whether there is an association between these findings and neonatal and pregnancy characteristics and seasonality. METHODS Newborns from three maternity hospitals in a Brazilian capital city were randomly selected to undergo dermatological assessment by dermatologists. RESULTS 2938 neonates aged up to thre...

As multithreaded programs become increasingly popular, plagiarism of multithreaded programs starts to plague the software industry. Although there has been tremendous progress on software plagiarism detection technology, existing dynamic birthmark approaches are applicable only to sequential programs, due to the fact that thread scheduling nondeterminism severely perturbs birthmark generation a...

PDL reduces the PDT light dose required to achieve persistent vascular shutdown, even at low PDL radiant exposures. We hypothesize that TS-mediated PDT enhances persistent vascular shutdown achieved with ensuing PDL therapy, primarily via endothelial cell damage (Mitra and Foster, 2008); mechanistic studies currently are underway. Dual phototherapy represents a potential new approach for more e...

* Corresponding author: Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, CA 92612. e-mail: [email protected] ABSTRACT Cryogenic sprays are used for cooling of human skin during laser treatments of hypervascular lesions, such as Port Wine Stain birthmarks. In this work, six straight-tube nozzles, including two commercial nozzles, are characterized by obtain...