An operationally simple, high yielding three-step cascade process is described for the direct conversion of indole-tethered ynones into functionalized quinolines. A single “multitasking” thiol reagent used to promote a dearomatizing spirocyclization, nucleophilic substitution, and one-atom ring expansion reaction under remarkably mild conditions. In addition, novel route thio-oxindoles describe...

2-monobromomethyl 1,4-dihydropyridines is selectively synthesized by bromination of the parent compound by 1.1 equivalents of pyridinium bromide perbromide in dichloromethane/pyridine at -20 °C. The same reagent in dichloromethane at 0 °C produce the 2,6-bis(bromomethyl) 1,4-dihydropyridines.

The fluorescent chiral tagging reagent, 4-(3-isothiocyanatopyrrolidin-1-yl)7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole (DBD-PyNCS), was utilized for the resolution of thiol enantiomers as diastereomeric derivatives. The reagent reacts with thiol enantiomers in the presence of pyridine to produce the corresponding dithiocarbamate diastereomers under mild reaction conditions (50 °C for 40 ...

The metal complexes of Azo dye; 4,4'-((methylene bis(3,l-phenylen)) bis (diazene-l,2-diyl)) bis(1,3-Benzenediol) are produced from 4,4`- methylenedianiline and Resorcinol were synthesized characterized by using several analytical spectral techniques. ligand its many chemo-physic methods like NMR, IR, UV-Vis, molar conductance measurement, melting point. conditions optimal reaction (for instance...

While thiol-based catalysts are widely employed for chemical protein synthesis relying on peptide thioester chemistry, this is less true selenol-based whose development in its infancy. In study, we compared different selenols derived from the selenocysteamine scaffold their capacity to promote thiol–thioester exchanges water at mildly acidic pH and production of thioesters bis(2-sulfanylethyl)a...

BACKGROUND Poly (ethylene glycol) (PEG) has attracted broad interest for tissue engineering applications. The aim of this study was to synthesize 4-arm -PEG-20kDa with the terminal group of diacrylate (4-arm-PEG-DA) and evaluate its dual functionality for decellularized porcine aortic valve (DAV) based on its mechanical and biological properties. METHODS 4-arm-PEG-DA was synthesized by graft ...

Thiol-mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors thiol-mediated uptake. High-content high-throughput screening the so far largest collection hypervalent iodine reagents affords that are more than 250 times active Ellman’s reagent and rival best dynamic inhibitors. Comparison with other reveals inhibition within one ...

Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), a dithiol that can be synthesized from l-aspartic acid in a few high-yielding steps that are amenable to a large-s...

Design of organic–inorganic hybrids by anchoring plasmonic materials such as gold nanoparticles (AuNPs) on self-assembled organic substrates is useful but challenging. Herein, in situ the surface a designed spherical assembly via AuS bond formation presented. First, thiol tailed pyrene derivative (2) undergoes solvent dependent self-assembly, transforming into an aggregate (2agg). The (-SH) ri...