An acquired hemorrhagic disorder developed in two patients in association with postsplenectomy thrombocytosis and leukocytosis during the course of the myeloproliferative syndrome. The presence of acquired von Willebrand's disease in these individuals was demonstrated by a decrease or absence of the larger von Willebrand factor (vWF) multimers, alteration of the repeating vWF multimeric "triple...

BACKGROUND Gastrointestinal bleeding is a common emergency that causes substantial mortality worldwide. Acute upper and lower gastrointestinal bleeding accounts for about 75,000 hospital admissions each year in the UK and causes the death of about 10% of these patients. Tranexamic acid has been shown to reduce the need for blood transfusion in surgical patients and to reduce mortality in bleedi...

Recurrent laryngeal nerve injury, hypocalcemia and bleeding are the most common severe complications in thyroid surgery. However, growing use of energy devices, hemostatic agents optical magnification techniques allows for a significant reduction such complications, while also improving quality intra- postoperative course reducing surgical times.

We performed a prospective, randomized, double-blind trial in 194 unselected patients to determine the safety and efficacy of low molecular weight heparin (Fragmin) compared with standard heparin as the initial treatment of acute venous thromboembolism. Ninety-eight patients received continuous intravenous heparin, and 96 patients received Fragmin for 5-10 days. Doses were adjusted to maintain ...

OBJECTIVE Assess the effectiveness of priming the extracorporeal circulation system with albumin-mannitol combined with ultrafiltration during extracorporeal circulation to reduce post-operative bleeding and transfusion requirements in heart surgery, as well as its impact on the fluid balance, coagulation and hematocrit parameters, re-operation for bleeding, ICU, and hospital length of stay. ...

BACKGROUND Elderly patients with atrial fibrillation are at higher risk of both ischemic and bleeding events compared to younger patients. In a prespecified analysis from the ENGAGE AF-TIMI 48 trial, we evaluate clinical outcomes with edoxaban versus warfarin according to age. METHODS AND RESULTS Twenty-one thousand one-hundred and five patients enrolled in the ENGAGE AF-TIMI 48 trial were st...

gastrointestinal melanoma (gim) is occasionally observed in general practice. we report a case of melanoma dispersed diffusely in the stomach and duodenum with no skin involvement.

conclusions sever thrombocytopenia and bleeding may be the presentation of brucellosis. case presentation we report on an eight-year-old boy who presented epistaxis and gum bleeding. the physical examination revealed petechiae, purpura, ecchymosis, and cervical while inguinal lymphadenopathy and splenomegaly were noted. brucella agglutinin titer was positive. after five days of specific therapy...

BACKGROUND Bleeding is associated with poor outcomes after percutaneous coronary intervention (PCI). Although arterial closure devices (ACDs) are widely used in clinical practice, whether they are effective in reducing bleeding complications during transfemoral PCI is uncertain. The objective of this study was to evaluate the effectiveness of ACDs for the prevention of vascular access site comp...