A 19-year-old man died after the intake of ten tablets of Ecstasy containing 3,4-methyl-enedioxy-N-ethylamphetamine (MDEA) as the main active ingredient. According to an eyewitness the symptoms of intoxication were strong sweating, sudden aggressiveness followed by hallucinations, subsequent failure of motoric coordination, severe spasms of arms and back, complete depression of the respiratory ...

Abstract In the ethanolamine (MEA) solution, during absorption and desorption of CO 2 undesired compounds are produced as a result degradation an amine. Degradation not only reduces capacity solution but also leads to many operational problems. Furthermore, measuring products is great importance in terms environmental issues. For determination MEA products, mainly chromatographic techniques use...

Evaluation of drug-drug interaction (DDI) involving circulating inhibitory metabolites of perpetrator drugs has recently drawn more attention from regulatory agencies and pharmaceutical companies. Here, using amiodarone (AMIO) as an example, we demonstrate the use of physiologically based pharmacokinetic (PBPK) modeling to assess how a potential inhibitory metabolite can contribute to clinicall...

The 3,4-methylenedioxy-methamphetamine (MDMA)-related designer drug 3,4-methylenedioxyethylamphetamine (MDEA, Eve) is a chiral compound that is mainly metabolized by N-deethylation and demethylenation during phase I metabolism. The involvement of several cytochrome P450 (P450) isozymes in these metabolic steps has been demonstrated by inhibition assays using human liver microsomes. However, a c...

Increasing evidence implicates the substance P (SP)/neurokinin-1 receptor system in anxiety and depression. However, it is not known whether emotional stimulation alters endogenous extracellular SP levels in brain areas important for processing of anxiety and mood, a prerequisite for a contribution of this neuropeptide system in modulating these behaviors. Therefore, we examined in rats whether...

CO2 capture from gas turbine exhaust is a possibility for emission reduction on oil and production platforms. A standard process based absorption in monoethanol amine (MEA). challenge that the cost of size weight equipment higher than land-based process. into (MEA) simulated Aspen HYSYSTM. The was obtained In-plant Cost EstimatorTM. base case assumptions which are earlier works assumed to be cl...

Natural gas (NG) requires treatment to eliminate sulphur compounds and acid gases, including carbon dioxide (CO2) hydrogen sulphide (H2S), ensure that it meets the sale transportation specifications. Depending on region is obtained from, concentrations of gases could reach up 90%. Different technologies are available capture CO2 H2S from NG absorb them with chemical or physical solvents; occasi...