The cytotoxic effects of bleomycin on HeLa cells in culture were enhanced by incubation of the cells with benzamide, a potent inhibitor of poly(ADP-ribose) polymerase, at concentrations at which benzamide alone did not show any cytotoxicity. Benzamide plus bleomycin display enhanced therapeutic effects against Ehrlich ascites tumor cells in vivo. On daily treatment with various doses of bleomyc...

Pharmacokinetics In mice, high concentrations of bleomycin are found in the skin, lungs, kidneys, peritoneum and lymphatics. Tumour cells of the skin and lungs have been found to have high concentrations of bleomycin in contrast to the low concentrations found in haematopoietic tissue. The low concentrations of bleomycin found in bone marrow may be related to high levels of bleomycin degradativ...

Magnolol, a compound extracted from the Chinese medicinal herb Magnolia officinalis, has been proved to exert multiple pharmacological effects, including anti-oxidant and anti-inflammation activities. In this study, how it influenced bleomycin-induced lung fibrosis of rats was investigated. A single intratracheal instillation of bleomycin (5 mg/Kg, sacrificed 7 and 28 days post bleomycin instil...

BACKGROUND Oxidative stress plays an important role in the pathogenesis of bleomycin-induced lung fibrosis and many antioxidant agents have been used for the treatment of this disease in animals. OBJECTIVES To evaluate the antioxidant effects of pomegranate seed extract (PSE) on bleomycin treated rats. MATERIALS AND METHODS Male Spraque - Dawley rats were divided into 5 groups: rats in grou...

The role of cigarette smoking in the development and outcome of pulmonary fibrosis is uncertain. In this study, we aimed to assess the effect of route of bleomycin exposure in the development of pulmonary fibrosis and the effects of cigarette smoke on bleomycin-induced lung fibrosis. We studied five groups of rats; 1-control group, 2-intratracheal bleomycin (IT), 3intratracheal bleomycin plus c...

There are several lines of evidence indicating that the DNA-cleaving activity of bleomycin determines its cytotoxicity. (1) Most bleomycin analogs and derivatives which degrade isolated DNA are also active against living cells and vice versal) ; (2) some bacterial mutants selected for sensitivity to bleomycin lacked DNA-repair systems',') ; and (3) more degradation of DNA was observed in cells ...

BACKGROUND Hemangioma is the most common tumor of neonatal period and it is almost always appeared by the end of the first week of life and can be found mostly in head and neck area. This study evaluated the synergistic effect of bleomycin, triamcinolone and epinephrine in treatment of hemangioma and arte-riovenous malformations. METHODS In this multicenter study, a combination of bleomycin,...

I performed an experiment on the relationship between 14C-Bleomycin and Glutathione in 'vivo; especially on the relationship of radioactivity and antibacterial activity, and the results will be reported here. 1) When Bleomycin and Glutathione were administered simultaneously and animals were killed after 30 minutes, decrease in Bleomycin concentration in every organ was observed. The decrease r...

Bleomycin administration results in well-described intracellular oxidative stress that can lead to pulmonary fibrosis. The role of alveolar interstitial antioxidants in this model is unknown. Extracellular superoxide dismutase (EC-SOD) is the primary endogenous extracellular antioxidant enzyme and is abundant in the lung. We hypothesized that EC-SOD plays an important role in attenuating bleomy...