The cytoplasmic side of the voltage-dependent Na+ channel pore is putatively formed by the S6 segments of domains I to IV. The role of amino acid residues of I-S6 and II-S6 in channel gating and local anesthetic (LA) block was investigated using the cysteine scanning mutagenesis of the rat skeletal muscle Na+ channel (Nav1.4). G428C uniquely reduced sensitivity to rested state or first-pulse bl...

We present the first direct measurement of ultrafast charge migration in a biomolecular building block - the amino acid phenylalanine. Using an extreme ultraviolet pulse of 1.5 fs duration to ionize molecules isolated in the gas phase, the location of the resulting hole was probed by a 6 fs visible/near-infrared pulse. By measuring the yield of a doubly charged ion as a function of the delay be...

The effects of lidocaine on sodium current in cardiac myocytes isolated from cat and guinea pig were investigated using the whole-cell variation of the patch-clamp technique. Lidocaine (43-200 microM) reduced sodium current during repetitive depolarizing pulses in a use-dependent manner. To clarify the nature of the use-dependent block, we characterized the time course of block development usin...

A novel multibody rocking model is developed to investigate the dynamic response of two stacked rigid blocks placed on a linear base isolation device. The used realistic statue-pedestal system subject pulse-like ground motions. analysis shows that, in general, increases safety level system. However, for large period pulses or small size blocks, isolator can amplify motion, resulting lower minim...

pulse echo b - scan imaging systems have been used for years in medical diagnosis. the theroy of such systems have been investigated by several researchers. in this paper, we introduce a new model for b - scan imaging system based on gaussian type transducer. an imaging system is normally identified by its point response function. this function describes the image of a single physical point obj...

In this paper, we solve Riccati equations by using the fractional-order hybrid function of block-pulse functions and Bernoulli polynomials (FOHBPB), obtained replacing x with xα, positive α. Fractional derivatives are in Caputo sense. With help incomplete beta functions, able to build exactly Riemann–Liouville fractional integral operator associated FOHBPB. This operator, together Newton–Cotes ...