In open pit mines, the slope stability of benches, inter-ramps, and overall is vital not only for economy extraction process but also safety personnel equipment. Geological discontinuities, geometry, other factors can induce different failure modes in hard rock masses such as planar, wedge sliding, toppling. Hence, analysis must be carried out carefully using a suitable technique by considering...

When the heart rate is accelerated, rate-dependent intraventricular block may occur. This block has been attributed to abnormal action potential prolongation in a diseased conducting pathway. Less often, intraventricular block develops during slowing of the heart rate and has been explained in terms of phase 4 depolarization in potentially automatic cells within the diseased fascicle. We tested...

In this paper, to explore the influence of expected speed on traffic flow in helical ramps, a new car-following model for intelligent connected vehicles (ICVs) was established mainly considering provided vehicle-to-everything (V2X) environment. On basis, sufficient conditions ensure stability stream were met and congestion propagation mechanism discussed by using linear analysis nonlinear analy...

Previous work has shown that the disparity vergence eye movement system responds to inward (i.e., convergent) ramp stimuli with both smooth and step-like behavior depending on target velocity. The responses to diverging ramp stimuli have not been previously studied, but convergence and divergence responses to other stimuli often show different behaviors. Converging and diverging 6 degrees/s ram...

G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs,...

animals had evolved independently for the longest period of time. The results were cross-referenced with the International Conservation Union's offi cial list of endangered species to identify the 10 priority animals. " When species have few close relatives there could be a number of reasons — they could have evolved for a long time and not created new species or their close relatives could hav...

US researchers are grappling with the issue of human embryonic stem cell research, in the face of severe restrictions in federal funding and lobby groups opposed to it. But California is forging ahead, following the November vote that gave support to an ambitious plan over the next ten years. Bolstering their plans, Robert Dynes, president of the University of California, is due to arrive in Br...