In medicine, blood groups play an active role. A noticeable relationship is observed linking ABO with the Wilbrand factor and vWF deficiency which results in hemorrhagic disorders, while increased levels are a risk for clotting. Previous investigations found that individuals group O have long hemorrhageand clotting time. The aim of current study to evaluate bleeding time different sex also. Thi...

Background Primary Sjögren’s syndrome (pSS) is an autoimmune rheumatic disease affecting the exocrine glands. Several pSS-associated clinical and laboratory parameters may predispose to thromboembolic risk, however clinical data is conflicting. My primary objective was to test whether whole blood clot formation is abnormal in pSS using several complementary approaches: Thromboelestrography (TEG...

The paper presents the results of study coagulation process whole blood with anticoagulant using method laser speckle correlation. clotting time dependence curves correlation coefficient have been presented and discussed. Analyzing changing trend these is possible to assess time, which prove capability for determining diseases coagulation.

Short-chain polyphosphate (polyP) is released from platelets upon platelet activation, but it is not clear if it contributes to thrombosis. PolyP has increased propensity to clot blood with increased polymer length and when localized onto particles, but it is unknown whether spatial localization of short-chain polyP can accelerate clotting of flowing blood. Here, numerical simulations predicted...

Many large, disease-related biobanks of serum samples have been established prior to the widespread use of proteomics in biomarker research. These biobanks may contain relevant information about the disease process, response to therapy or patient classifications especially with respect to long-term follow-up that is otherwise very difficult to obtain based on newly initiated studies, particular...

I T HAS been demonstrated, qualitatively, that the rate of blood coagulation is related to the presence of blood platelets. This relationship has been known to exist in bird blood since the investigations of Delezenne (I). In mammalian blood, however, conflicting data and opinions regarding the role of platelets in coagulation have been published during the past half-century. Only in the past d...

A viscoelastometer, the SonoClot Coagulation Analyzer, has been proposed for use in the evaluation of platelet function. The purpose of this study was to evaluate systematically this instrument when used with whole blood. Under laboratory conditions, the coefficient of variation (cv) of determinations of whole blood activated clotting time (ACT) on the instrument was approximately 7.0 percent. ...

A scientist whose work with the blood coagulation system led to effective treatments for people with hemophilia is the recipient of the ninth annual Bristol-Myers Squibb Award The prize carries with it a $50 000 award and a silver medallion. In research that spanned more than 4 decades, Dr Davie hypothesized, elucidated, and defined the blood clotting system. His work began as a graduate studen...

The antithrombotic action of a heparin is not necessarily confined to its effects on the clotting mechanism. Yet we restrict ourselves here to a discussion of the action of heparin on thrombin generation in platelet poor and platelet rich plasma for two reasons. In the first place it is more likely than not that inhibition of the clotting mechanism is at least one of the major working arms of h...